Ex vivo assessment of neointimal characteristics after drug-eluting stent implantation: Optical coherence tomography and histopathology validation study

Imanaka, Tadayuki; Fujii, Kenichi; Hao, Hiroyuki; Shibuya, Masabumi; Saita, Ten; Kawakami, Rika; Fukunaga, Masao; Kawai, Kenji; Miki, Kojiro; Horimatsu, Takahiro; Sumiyoshi, Akinori; Nishimura, Masaharu; Hirota, Seiichi; Masuyama, Tohru; Ishihara, Masaharu

doi:10.1016/j.ijcard.2016.07.110

Cited by 27 publications

(27 citation statements)

References 15 publications

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“…Following previous reports, we have analyzed the four elementary OCT patterns of neointima: homogeneous, heterogeneous, layered, and lipid‐rich. The homogeneous neointima pattern correlated in earlier reports with a high proportion of connective tissue and smooth muscle cells in histopathology indicating favorable vessel healing . Whereas, heterogeneous neointima was found to correlate with higher presence of fibrin as compared to the homogeneous pattern and was associated with poorer clinical outcomes .…”

Section: Discussionsupporting

confidence: 84%

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An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

Legutko

Gil²,

Kałuża

et al. 2017

Cathet Cardio Intervent

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Section: Discussionsupporting

confidence: 84%

“…It has been demonstrated that certain morphologic patterns of in‐stent neointima in OCT correlate with histopathologic characteristics . Following previous reports, we have analyzed the four elementary OCT patterns of neointima: homogeneous, heterogeneous, layered, and lipid‐rich.…”

Section: Discussionmentioning

confidence: 96%

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

Legutko

Gil²,

Kałuża

et al. 2017

Cathet Cardio Intervent

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“… 23) However, as shown in Figure 4 , a non-homogeneous pattern with an invisible stent strut on OCT imaging can identify the presence of lipids within neointima. 24) …”

Section: Atherosclerotic Change Inside Neointimamentioning

confidence: 99%

Formation and Transformation of Neointima after Drug-eluting Stent Implantation: Insights from Optical Coherence Tomographic Studies

2017

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After coronary stent implantation, neointima formation resembles the wound healing process as it involves the sequential processes of inflammation, granulation, and remodeling. Because antiproliferative drugs and polymers of drug-eluting stents (DESs) delay vascular healing compared with bare metal stents, fibrin deposition can remain long after stent implantation, or inflammation can be excessive. Delayed vascular healing can be associated with adverse clinical outcomes including DES thrombosis or restenosis, and poor endothelization of DES neointima can accelerate neoatherosclerotic change inside the neointima, further contributing to luminal restenosis or neointimal instability. Despite the lack of correlation between pathologic and optical coherence tomography (OCT) findings, OCT assessments of neointima under various circumstances can reveal vascular responses to stent therapy. Homogeneous, heterogeneous, and layered neointima patterns can be recognized by OCT and can change with time. Homogeneous neointima might be associated with better clinical outcomes after DES implantation, whereas non-homogeneous neointima or neoatherosclerotic change can be associated with poorer clinical outcomes. However, limited data are currently available, and further studies are required to comprehensively address these questions.

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“…1c); and (iv) NA, lipid-laden neointima (marked signal attenuation with a diffuse border ( Fig. 1d) [14][15][16][17][18]. Peri-strut low-intensity area (PLIA) was defined as a region around the struts with lower homogeneous intensity than the surrounding tissue on OCT images without signal attenuation [19,20].…”

Section: Optical Coherence Tomography Image Acquisition and Analysismentioning

confidence: 99%

Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography

Yamamoto

Liu

Higuma

et al. 2017

Coronary Artery Disease

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Ex vivo assessment of neointimal characteristics after drug-eluting stent implantation: Optical coherence tomography and histopathology validation study

Cited by 27 publications

References 15 publications

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents

Formation and Transformation of Neointima after Drug-eluting Stent Implantation: Insights from Optical Coherence Tomographic Studies

Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography

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