Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: Two Unusual Presentations of a Rare Tumor

Castro, Eumênia Costa da Cunha; Parwani, Anil V.

doi:10.1155/2012/190581

Cited by 15 publications

(8 citation statements)

References 14 publications

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“…Clinically, renal ES patients treated with seven cycles of chemotherapy including vincristine, cyclophosphamide, dactinomycin and doxorubicin after radical nephrectomy remained disease-free for 7.5 years. Moreover, postoperative metastases to the liver and lymph nodes were treated with chemotherapy (six cycles of vincristine, doxorubicin and cyclophosphamide), and the response rate was approximately 90% based on the RECIST guidelines[10].…”

Section: Discussionmentioning

confidence: 99%

Ureteral Ewing’s sarcoma in an elderly woman: A case report

Li¹,

Bi²

2019

WJCC

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BACKGROUNDEwing’s sarcoma (ES) is regarded as a skeletal tumor, with few instances of extra-skeletal ES. A primary ES in the ureter is extremely rare.CASE SUMMARYWe report the case of a 69-year-old woman who presented with intermittent flank pain and hematuria and was found to have a mass in the left ureter. Pathology of the excised mass indicated ES. The clinical treatment and pathologic characteristics in this case, and a review of the literature describing ES in the urinary system, are presented.CONCLUSIONDue to the rarity and malignancy of ES in ureter, early diagnosis and prompt surgical treatment are critical.

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Section: Discussionmentioning

confidence: 99%

Ureteral Ewing’s sarcoma in an elderly woman: A case report

Li¹,

Bi²

2019

WJCC

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“…Clinically, an ESK patient treated with seven cycles of chemotherapy (vincristine, cyclophosphamide, dactinomycin, and doxorubicin) after radical nephrectomy remained disease-free for 7.5 years [7]. Further, post-operative residual renal mass involving liver and lymph nodes was treated with chemotherapy (i.e., six cycles of vincristine, doxorubicin, and cyclophosphamide); the response was estimated at 90% based on the Recist guidelines [8]. Not surprisingly, the patients may not benefit from the multi-modal therapy owing to the more aggressive nature of the disease (i.e., late diagnosis, advanced stage at presentation, early metastasis, etc.).…”

Section: Discussionmentioning

confidence: 99%

Primary Ewing sarcoma of the kidney: a case report and treatment review

et al. 2017

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Ewing sarcomas/primitive neuroectodermal tumors (ES/PNET) of the kidney are rarely found high-grade malignant tumors, offering poor prognosis. Although established treatment guidelines for ES of kidney are scarce, a multi-modality treatment approached is typically implemented. Herein, we report a 14-year-old female patient with ES of right kidney. Post-nephrectomy disease recurrence was treated with chemotherapy (i.e., vincristine, doxorubicin and cyclophosphamide); marked reduction in tumor size (i.e., from 18.5 9 11.3 cm 2 to 3.7 9 2.2 cm 2 ; *96% reduction in size) as per computed tomography images was observed. We present our treatment experience and review from the available literature.

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“…Skin, soft tissue and viscera (kidney, lungs, adrenal) and the retroperitoneum are less commonly affected [3] . ES/PNET of the kidney with pulmonary tumor embolism is very unusual, with only two cases reported to date [4,5] . A similar presentation of renal PNET with pulmonary embolism was reported in a 30-year-old male and 21-year-old female patient, with tumor resection and thrombectomy done in both cases and later confirmed on histopathology.…”

Section: Discussionmentioning

confidence: 99%

Peripheral primitive neuroectodermal tumor of the kidney presenting with pulmonary tumor embolism: A case report

Chinnaa

Das

Sharma

et al. 2014

WJR

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Peripheral primitive neuroectodermal tumor (PNET) of the kidney is a rare, aggressive tumor known for its recurrence and metastatic potential. Despite the frequency of venous extension to the renal veins and inferior vena cava, pulmonary tumor embolism at the initial presentation is not common. We report a case of 22-year-old female with PNET of the kidney who presented with tumor embolism in the inferior vena cava (IVC) and bilateral pulmonary artery. The patient underwent surgical resection and histopathological analysis confirmed the presence of tumor within the IVC and pulmonary arteries. The patient received adjuvant chemotherapy and is currently doing well on follow-up. Core tip: Traditionally, an aggressive renal mass with pulmonary tumor embolism is an entity well described in renal cell carcinomas. However, renal primitive neuroectodermal tumor (PNET), a rare and aggressive tumor, can have a similar presentation. The severity of the clinical manifestations of pulmonary tumor embolism is highly variable and less predictable. Bland thrombus often mimics tumor emboli in imaging and histopathology is often confirmatory. Tumoral extension into the pulmonary artery is not necessarily associated with pulmonary metastasis. Surgical removal of the thrombus along with the primary tumor followed by adjuvant chemotherapy may prolong the survival in these patients.Chinnaa S, Das CJ, Sharma S, Singh P, Seth A, Purkait S, Mathur SR. Peripheral primitive neuroectodermal tumor of the kidney presenting with pulmonary tumor embolism: A case report. World

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Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: Two Unusual Presentations of a Rare Tumor

Cited by 15 publications

References 14 publications

Ureteral Ewing’s sarcoma in an elderly woman: A case report

Ureteral Ewing’s sarcoma in an elderly woman: A case report

Primary Ewing sarcoma of the kidney: a case report and treatment review

Peripheral primitive neuroectodermal tumor of the kidney presenting with pulmonary tumor embolism: A case report

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