Ewing's sarcoma

Treatment and Outcomes of Ewing Sarcoma in Turkish Adults: A Single Centre Experience

“…Similar to other studies, 19% of the patients were metastatic. The most common metastasis sites were lungs (40%) and bones (40%) (Obata et al, 2007;Balamuth and Womer, 2010).…”

“…Another cause of the different clinical outcome is that it is more feasible to apply more effective local therapy in extremity primary ES. It is difficult to achieve successful local treatment in both abdominopelvic and thoracal disease, either with surgery or radiation, due serious morbidities and mortalities (Balamuth and Womer, 2010).…”

Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies

“…Linked to their proliferative, differentiation and apoptotic properties, both GH and insulin-like growth factor 1 (IGF1) have been identified as risk factors for certain malignancies (1)(2)(3)(4)(5), even in the pediatric age group and young adults (6)(7)(8). There is also evidence that most tumors and transformed cells display increased IGF1 receptor (IGF-1R) concentration and high IGF1R mRNA, causing enhanced IGF1 binding (9,10), leading to the axiom that overexpression of IGF1R is a pre-requirement for acquisition or progress of malignant tumors (11).…”

Sarcoma de Ewing: epidemiologia e prognóstico dos pacientes tratados no Instituto de Oncologia Pediátrica, IOP-GRAACC-UNIFESP

“…Presence of this translocation in the tumor is a diagnostic factor for Ewing, but it is not prognostic. Presence of the same translocation in the patient's peripheral blood, or in bone marrow aspirate away from the area of tumor, is a sign of disseminated disease and therefore of poor prognosis (22) . In our clinic, genetic analysis on this translocation began in 2008, but it has not yet been possible to assess these data.…”