Ewing’s Sarcoma

Jürgens, H.; Donaldson, Sarah S.; Göbel, U.

doi:10.1007/978-3-642-84722-6_24

Cited by 8 publications

(4 citation statements)

References 80 publications

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“…4,6 90% of patients are below 20 years of age, and it is extremely rare for patients over 30 years. 6,8,9 Its presentation in 70% of patients is a solitary tumour with extra-osseous extent. 4 25% of cases are diagnosed with metastasis at presentation.…”

Section: Discussionmentioning

confidence: 99%

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Delayed Diagnosis of Ewing's Sarcoma of the Right Humerus Initially Treated as Chronic Osteomyelitis: A Case Report

Tow

Tan

2005

J Orthop Surg (Hong Kong)

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We report a case of limited stage Ewing's sarcoma which was initially treated as chronic osteomyelitis for 3 years. A 24-year-old man presented with a one-week history of pain in the right arm and fever, with histology suggestive of osteomyelitis of the affected humerus. He developed multiple relapses of pain and fever; each episode responded to antibiotic treatment. A second biopsy was performed 3 years later and confirmed a diagnosis of Ewing's sarcoma. Despite a 3-year delay in diagnosis, the disease remained localised. This case report highlights an atypical facet of the natural history of Ewing's sarcoma: a response to antibiotic and anti-inflammatory agents, and the limited stage of the disease despite a misdiagnosis of 3 years. This suggests the possibility that anti-inflammatory agents exert an inhibitory effect on the tumour growth. We also highlight the newer histologic and immunologic staining used in the diagnosis of Ewing's sarcoma.

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Section: Discussionmentioning

confidence: 99%

“…10 Fever is present in patients with disseminated disease. 9 The prognosis for Ewing's sarcoma is unfavourable, with a less than 10% chance of survival in 5 years if untreated; however, with chemotherapy, the survival rate is over 60%. 4,8 The prognosis is also worse with increasing age.…”

Section: Discussionmentioning

confidence: 99%

Delayed Diagnosis of Ewing's Sarcoma of the Right Humerus Initially Treated as Chronic Osteomyelitis: A Case Report

Tow

Tan

2005

J Orthop Surg (Hong Kong)

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“…ES, pPNET and AT share the reciprocal chromosomal translocation t(11;22)(q24;q12), resulting in EWS/FLI‐1 gene fusion transcripts identifiable in 90% of cases; the remaining cases have other aberrations, such as the translocation t(21;22)(q22;q12) associated with EWS/ERG hybrid transcripts (Dockhorn‐Dworniczak et al, 1994). ES and pPNET are rapidly disseminating malignancies, presenting in 25% of patients with lung metastasis and multiple bone involvement (Jürgens et al, 1992). Despite aggressive treatment strategies, such as high‐dose chemotherapy with stem‐cell rescue in combination with surgical and/or extended radiotherapy, the prognosis for patients with metastatic disease remains poor (Paulussen et al, 1998).…”

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confidence: 99%

Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)

et al. 2000

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We investigated the cytotoxic responsiveness of 40 cell lines derived from representatives of the Ewing's sarcoma family of tumours (ESFT), i.e., Ewing's sarcoma (ES), peripheral primitive neuroectodermal tumour (pPNET) and Askin tumour (AT), to tumour necrosis factor–related apoptosis‐inducing ligand (TRAIL). Incubation with TRAIL at 100 ng/ml induced cell death at 24 hr in 19 of 26 ES, 11 of 12 pPNET and 2 of 2 AT cell lines. Half‐maximal cell death concentrations (IC50 values) varied from 0.1 to 20 ng/ml. TRAIL displayed potent cytotoxic activity against freshly derived ESFT cell isolates. Cytotoxicity was associated with phosphatidylserine expression and internucleosomal DNA fragmentation, features characteristic of apoptosis. The apoptotic programme in the sensitive ESFT VH‐64 cell line revealed TRAIL‐induced activation of FLICE/MACH1 (caspase‐8) and CPP32/Yama/apopain (caspase‐3) and processing of the prototype caspase substrate poly(ADP‐ribose) polymerase. In addition, TRAIL provoked a collapse of the mitochondrial transmembrane potential (ΔΨm), parallelled by a reduction in ATP levels and release of cytochrome c from mitochondria into the cytosol. Inhibition of caspase‐8 and caspase‐3 by zIETDfmk and zDEVDfmk, respectively, substantially prevented TRAIL‐induced apoptosis. However, zIETDfmk, but not zDEVDfmk, reduced TRAIL‐mediated ΔΨm dissipation, indicating that TRAIL causes mitochondrial dysfunction through caspase‐8 acting upstream of mitochondria. While macromolecule synthesis inhibitors (actinomycin D, cycloheximide) augmented susceptibility to TRAIL in TRAIL‐responsive cell lines, these agents did not render TRAIL‐resistant cell lines susceptible to TRAIL. However, the proteasome inhibitor MG132 sensitised to TRAIL in resistant cell lines. Collectively, these results show that TRAIL initiates effective death in the vast majority (80%) of cell lines derived from ESFT. Since TRAIL provoked cell death in ESFT ex vivo, this cytokine may be a promising drug for the treatment of ESFT in vivo. Int. J. Cancer 88:252–259, 2000. © 2000 Wiley‐Liss, Inc.

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“…The specific detail of Vauxhall's programme of restructuring involved stock reduction, delayering, reduction of relief men and indirect labour [18], and all in the context of reduced union influence through its replacement by teamworking. In practice, what the company achieved was some measure of all but the last of these:…”

Section: Vauxhall -'Engage and Change'mentioning

confidence: 99%

From ‘embrace and change’ to ‘engage and change’: trade union renewal and new management strategies in the UK automotive industry?

Stewart

Wass

1998

New Technol Work Employ

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This article focuses on the relationship between the introduction of new management techniques (NMTs), trade union responses and employee attitudes in the automotive industry in the UK. In contrast to a prevailing pessimistic prognosis for the survival of traditional industrial relations in the ‘new management’ environment, unions remain as an independent and dissenting force. Paradoxically, one of the significant features driving union recovery has been the opportunities presented by the very nature of NMTs themselves which, among other things, have opened the possibility for increased local autonomy.

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Ewing’s Sarcoma

Cited by 8 publications

References 80 publications

Delayed Diagnosis of Ewing's Sarcoma of the Right Humerus Initially Treated as Chronic Osteomyelitis: A Case Report

Delayed Diagnosis of Ewing's Sarcoma of the Right Humerus Initially Treated as Chronic Osteomyelitis: A Case Report

Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)

From ‘embrace and change’ to ‘engage and change’: trade union renewal and new management strategies in the UK automotive industry?

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