Ewing's sarcoma: Metastatic tumor to the jaw

Ewing's Sarcoma Family Tumors in the Jaws: Case Report, Immunohistochemical Analysis and Literature Review

“…Other authors have also misdiagnosed cases with clinical features similar to those of our case as being cysts (3,(19)(20)(21). Moreover, trauma (22)(23)(24) and acute inflammatory lesions (1, 3, 24-29, 30, 31) were also mentioned several times as provisional diagnosis. With regard to phenotypic aspects, we observed highly positive expression of CD99, vimentin, S-100 protein and NSE, representing ES family tumor with neuroectodermal differentiation or ES/pPNET (32)(33)(34)(35).…”

Ewing’s Sarcoma of Mandible: A Very Rare Disease and Review of Indian Literature

“…Ewing's sarcoma is the second most common primary malignant tumor of bone among children and adolescent. [3] Swelling, pain, parasthesia, and loose teeth are frequent symptoms. Radiographically, it is most often seen as destructive expansile, mottled radiolucent lesion, which may produce a laminated periosteal reaction.…”

Ewing's Sarcoma of Mandible – A Rare Neoplasm

“…Only 2% involve the mandible and the maxilla is involved one eighth as often as the mandible [I]. This tumour was originally described by James Ewing in 1921 and was believed to arise from undifferentiated osseous mesenchymal cells, however, the cell of origin is not equivocally established [2]. Cytogenetic studies suggest the possibility of neural origin for Ewing's sarcoma [3].…”

“…Ewing's sarcoma, particularly in children, poses difficulty in arriving at a specific diagnosis, however, this can be overcome with the help of histopathological and immunohistochemical evaluation [2]. There is no formal staging system available for the tumour and it is usually classified as localized, metastatic or recurrent [5].…”

“…Patient was managed preoperatively by chemotherapy with 5 pre-operative administrations of cyclophosphamide (150 mg/m 2 ) on days I to 7. and doxorubin (35mg/m 2 ) on day 8. and maintenance chemotherapy. The surgical procedure consisted of extirpation of the involved side by hemimandibulectomy (Fig-7).…”