Ewing's sarcoma in the spinal canal of T12‑L3: A case report and review of the literature

Yan, Dajun; Zhang, Jie; Zhong, Dequan

doi:10.3892/ol.2019.10958

Cited by 3 publications

(2 citation statements)

References 32 publications

(41 reference statements)

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“…ES/PNETs are seen as small round cell tumors. The 32-kDa cell surface glycoprotein has also demonstrated significant use as a screening tool given its high sensitivity (as high as 95%), although specificity is low[ 63 ]. Immunohistochemical staining for CD99 is essential to support the diagnosis of ES/PNET from other small round cell tumors.…”

Section: Discussionmentioning

confidence: 99%

Primary adrenal Ewing sarcoma: A systematic review of the literature

Manatakis,

Tsouknidas,

Mylonakis

et al. 2023

World J Clin Cases

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β cells are the main cells responsible for the hypoglycemic function of pancreatic islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose levels in the human body. β cells are regulated by various factors, among which neurotransmitters make an important contribution. This paper discusses the effects of neurotransmitters secreted by various sympathetic and parasympathetic nerves on β cells and summarizes the mechanisms by which various neurotransmitters regulate insulin secretion. Many neurotransmitters do not have a single source and are not only released from nerve terminals but also synthesized by β cells themselves, allowing them to synergistically regulate insulin secretion. Almost all of these neurotransmitters depend on the presence of glucose to function, and their actions are mostly related to the Ca2+ and cAMP concentrations. Although neurotransmitters have been extensively studied, many of their mechanisms remain unclear and require further exploration by researchers.

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Section: Discussionmentioning

confidence: 99%

Primary adrenal Ewing sarcoma: A systematic review of the literature

Manatakis,

Tsouknidas,

Mylonakis

et al. 2023

World J Clin Cases

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“…Among these tumors, Central Nervous System (CNS) sarcomas represent an extremely rare subgroup with less than 1% of all sarcomas, originating mostly as a result of distant metastasis, direct invasion to the brain parenchyma and radiation associated sarcomas in young individuals [9,10]. Undifferentiated sarcoma, fibrosarcoma and malignant fibrous histiocytoma were among the most commonly found subtypes of CNS sarcomas in the past decade [11]. In addition to previous reports of incidence rate of CNS sarcoma of 3 per 10 million person-years, primary Intracranial Sarcomas (IS) which were first described in 1929, have incidence rate from 0.1 to 4.3% based on multiple types of studies with variable definition of primary IS [12,13].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic Evaluation of Central Nervous System Sarcomas in Iran: A 2009-2014 Survey

AS¹,

Seddighi²,

Nikouei³

et al. 2021

austinjclincaserep

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Sarcomas rise from mesenchymal layers and may transform to variable malignant lesions in multiple organs systems. Although they are mostly localized, many of them have predilection of distant sites away from their primary origins and subsequent metastasis to different anatomical locations of body. Soft Tissue Sarcomas (STSs) represent one percent of adult and about 7% of pediatric malignancies. Although insignificant in number, these tumors may complicate patient’s overall health status compared with other malignancies, because of their numerous subtypes and variable features which may pose an everlasting challenge to both clinical and surgical treatment strategies. Existence of these complications and a relatively small available data regarding Central Nervous System’s (CNS) sarcomas, encouraged authors to conduct a retrospective study in a 6-year period to evaluate the specific epidemiological features of CNS sarcomas, including brain, spinal cord and meningeal layer sarcomas extracted from Iranian National Cancer Registry (INCR). Our study revealed CNS sarcoma’s trend to affect males more than females, affecting them most in their midlife and a higher prevalence of brain involvement compared to spinal cord and meningeal layers. Also, we have provided detailed morphological features of the tumors, as well as patient’s geographical distribution, with Northern parts of Iran have the lowest incidence rate (10.06%). Moreover, our analysis of crude rate revealed lower Age Specific Incidence Rate (ASIR) of CNS Sarcomas than expected number of cases compared to standard world population by World Health Organization (WHO)’s ASIR as 0.035 person per 100000-years. Authors believe this report of epidemiological assessment of CNS sarcomas in Iran could act as a foundation for better understanding the underlying pathophysiological mechanism as it is the first survey in developing countries and selection of optimal treatment strategies based on improved understanding of these neoplasms.

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Primary intradural extramedullary extraosseous Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (PIEES/PNET) of the thoracolumbar spine: A case report and literature review

Liu

Zhang

et al. 2021

Open Medicine

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We present a rare case of a primary intradural extramedullary Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (PIEES/PNET) in the thoracolumbar spine and review the current literature. We describe the imaging manifestations, pathological features, surgical methods, and patient survival to shed light on the clinical management of this rare tumor. A 32-year-old man experienced progressive low back pain for more than 1 month. An intradural extramedullary tumor from T12 to L2 was detected on magnetic resonance imaging. He underwent a thoracolumbar laminotomy for decompression, complete excision of the intradural extramedullary tumor, and internal fixation with pedicle screws. A histopathological examination confirmed that the tumor was a PIEES/PNET via an immunohistochemical study of the surgically resected tissues. Postoperatively, the patient received chemotherapy and radiotherapy. No recurrence, metastasis, or failure of internal fixation were noted at a 17-month post-surgery radiographic examination. PIEES/PNET of the thoracolumbar spine is extremely rare. Treatment is difficult because the current literature is sparse and cases are rare. Complete resection combined with chemotherapy and radiotherapy effectively reduces recurrence and metastasis.

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Ewing's sarcoma in the spinal canal of T12‑L3: A case report and review of the literature

Cited by 3 publications

References 32 publications

Primary adrenal Ewing sarcoma: A systematic review of the literature

Primary adrenal Ewing sarcoma: A systematic review of the literature

Epidemiologic Evaluation of Central Nervous System Sarcomas in Iran: A 2009-2014 Survey

Primary intradural extramedullary extraosseous Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (PIEES/PNET) of the thoracolumbar spine: A case report and literature review

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