Ewing's Sarcoma: Epidemiology and Prognosis for Patients Treated at the Pediatric Oncology Institute, Iop-Graacc-Unifesp

Abstract

Objective: To outline the epidemiological profile and prognosis for Ewing's sarcoma in the Brazilian population. Material and Methods: The medical records of 64 patients with intraosseous Ewing's sarcoma who were treated at the Pediatric Oncology Institute, IOP-GRAACC-Unifesp, between 1995 and 2010, were retrospectively evaluated. Results: The statistical analysis on the data obtained did not correlate factors such as sex, trauma, pathological fracture and time taken for case diagnosis with the treatment outcome. Factors such as initial metastasis, lung metastasis, tumor site, age, recurrence and type of surgery showed results corroborating what has been established in the literature. Conclusion: The prognosis in cases of Ewing's sarcoma was mainly influenced by the presence of metastases at the time of diagnosis.

Extraosseous Ewing Sarcoma Presenting with Inferior ST-Elevation Myocardial Infarction and Systemic Emboli due to Tumor Thrombus and Invasion of the Left Atrium

“…Standard management of extraosseous Ewing sarcoma involves chemotherapy coupled with local therapy in the form of surgery and/or radiation therapy. Local therapy alone leads to relapse rates of 80-90%, but fortunately, Ewing sarcoma is typically highly responsive to chemotherapy and radiation therapy [3]. Though fewer than 30% of patients have metastases at the time of diagnosis, EFT is always considered a systemic disease due to its tendency for early dissemination.…”

“…Most secondary tumors arise from primary malignancies such as lung and breast cancer. The most common secondary or metastatic cardiac tumor is melanoma in over half of reported cases, followed by breast, lung, and esophageal cancer, as well as lymphomas and leukemia [3,5]. While rare, there are a few reports of cardiac metastases in adult Ewing sarcoma with involvement of the right ventricle and the pericardium, with two cases each [7,8].…”

Proximal Radius Ewing’s Sarcoma Resection Followed by Migration of the Proximal Radius: Report of Two Cases

“…Ewing's sarcoma rarely presents in the radius [10]; management of such tumor is surgery and chemotherapy mainly. Many surgical choices were presented over the years; these options include en bloc excision (mainly for benign lesion), resection with/without construction or amputation [11].…”

Electro-therapies for sarcomas

“…It forms from a certain kind of cell in bone or soft tissue and may be found in the bones of the legs, arms, feet, hands, chest, pelvis, and spine as shown in Figure 2. 5 It is classified as a group of small round blue tumor cells as shown in Figure 3, which includes neuroblastoma, alveolar rhabdomyosarcoma and lymphoblastic lymphoma. 6 The Ewing's sarcoma family of tumors (ESFT) includes classic Ewing sarcoma (ES), Askin tumor, and peripheral primitive neuroectodermal tumor (PNET).…”