Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients.

Abstract

Based on our experience and a review of the literature, we concluded that the natural history and the prognosis of the Ewing's family of tumors in adults are not different from that found in children. A greater tumor bulk in adults may explain the less favorable prognosis previously reported by others. Outcome could be adequately monitored by a simple prognostic index.

Treatment and Outcomes of Ewing Sarcoma in Turkish Adults: A Single Centre Experience

“…Similarly, in Grier et al's study, the survival rate worsened with advanced age (Grier et al, 2003). But some studies have shown that age has no significant influence on survival (Fizazi et al, 1998;Bacci et al, 2000). Consequently, this issue must be identified with randomized prospective trials.…”

IFN-β induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7

“…Innovative approaches are therefore under investigation to increase disease-free survival (Horowitz et al, 1997;Fizazi et al, 1998). The hypothesis that interferons (IFNs) may reduce carcinogenesis has been supported by the results of numerous studies (Gutterman, 1994;Tanneberger and Harelia 1996;Borden, 1998).…”

Survival outcome among patients with Ewing’s sarcoma of bones and joints: a population-based cohort study

“…However, there is no consensus regarding any critical cutoff size that might indicate a completely different prognosis for this disease. [19][20][21][22][23] In a study on 182 patients, Fizazi et al 24 found that tumor size greater than 10 cm was an independent prognostic factor for survival. Canter 25 also recommended that patients with tumors larger than 10 cm should accept neoadjuvant chemotherapy and investigational therapies, because they were at a high risk of relapse and disease-specific death.…”