Evomonoside: The Cytotoxic Cardiac Glycoside from<i>Lepidium apetalum</i>

Hyun, Jin‐Won; Shin, Jin-E.; Lim, Kyoung-Hwa; Sung, Min-Sook; Park, Jong-Wan; Yu, Ju-Hyun; Kim, Byoung-Kak; Paik, Woo-Hyun; Kang, Sam-Sik; Park, Jae-Gahb

doi:10.1055/s-2006-958084

Cited by 8 publications

(4 citation statements)

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“…The most important CG-containing plant families are Apocynaceae, incl. Asclepiadaceae (Adenium [1], Cerbera [2], Cryptostegia [3], Nerium [4,5], Parepigynum [6,7], Periploca [8][9][10], Strophanthus [11][12][13][14][15], Thevetia [16][17][18][19][20][21][22]), Brassicaceae (Erysimum [23][24][25][26][27][28][29], and Lepidium [30]), Celastraceae (Euonymus [31,32], and Lophopetalum [33]), Convallariaceae (Convallaria [34][35][36][37][38][39][40][41][42][43][44][45]), Crassulaceae (Cotyledon [46], and Tylecodon [47,48]), Hyacinthaceae (Schizobasis [49], and Urginea …”

Section: Introductionmentioning

confidence: 99%

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Babula¹,

Masařík²,

Adam³

et al. 2013

ACAMC

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The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action is very complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac glycosides. The aim of this review is to present cardiac glycosides not only as pharmaceuticals used in the management of heart failure, but also as potent cytotoxic agents with potential uses in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Babula¹,

Masařík²,

Adam³

et al. 2013

ACAMC

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“…From the stems of C. spinarum, 12 compounds namely scopoletin (1) (Vasconcelos et al, 1998), (À)-nortrachelogenin (2) (Achenbach et al, 1983;Lin et al, 1999), (À)carissanol (3) (Khamlach et al, 1990), (À)-carinol (4) (Khamlach et al, 1990), (+)-cycloolivil (5) (Ghogomu-Tih et al, 1985), (+)-8-hydroxypinoresinol (6) (Yeo et al, 2004), (À)-olivil (7) (Yeo et al, 2004), (À)-secoisolariciresinol (8) (Xie et al, 2003), (+)-pinoresinol (9) (Xie et al, 2003), carissone (10) (Achenbach et al, 1985), digitoxigenin-3-Ob-D-digitalopyranoside (11) (Cabrera et al, 1993) and evomonoside (12) (Hyun et al, 1995) were isolated and identified by comparison of their spectral data with reported values (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Bioactive Compounds from Carissa spinarum

Wangteeraprasert

Lipipun

Gunaratnam

et al. 2012

Phytotherapy Research

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In our continuing efforts to find new antiherpetic agents from plants, an extract prepared from the stems of Carissa spinarum L. was found to possess appreciable activity against herpes simplex viruses (HSV I and II). A chemical study of this plant was then initiated, and this led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds were evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects. The cardiac glycoside evomonoside was found to be the only antiherpetic principle, showing moderate activity against herpes simplex virus types I and II in the inactivation method. The lignans (-)-carinol, (-)-carissanol and (-)-nortrachelogenin exhibited cytotoxicity against breast (MCF7) and lung (A549) cancer cells. Moderate anti-DPPH free radical activity was observed for all the lignans. None of the isolates showed antibacterial activity.

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“…Besides the structures of the aglycones, the length [11], [13], [14], and the modifications [10] of the glycosidic chains of cardenolides affected their bioactivity.…”

Section: Resultsmentioning

confidence: 99%

Steroidal Saponins fromMyriopteron extensumand Their Cytotoxic Activity

Yang¹,

Li²,

Gao³

et al. 2004

Planta med

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Two new steroidal saponins, extensumsides A ( 1) and B ( 2), were isolated from the whole plants of Myriopteron extensum (Wight) K. Schum. Their structures were elucidated as 17 beta-uzarigenin-3- O- beta-glucopyranosyl-(1-->6)- beta-glucopyranosyl-(1-->4)- beta-thevetopyranosyl-(1-->4)- beta-cymaropyranoside ( 1) and 12-(3-methylbut-2-enoyloxy)pregn-5-en-20-one 3- O-[beta-cymaropyranosyl-(1-->4)-beta-cymaropyranosyl-(1-->4)-beta-thevetopyranosyl-(1-->4)-(6- O-sulfo-beta-glucopyranoside)] ( 2) on the basis of chemical and spectral evidence. Extensumside A exhibited significant cytotoxicity against eight cancer cell lines with a mean GI (50) value of 0.346 microg/mL.

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Evomonoside: The Cytotoxic Cardiac Glycoside fromLepidium apetalum

Cited by 8 publications

References 0 publications

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Bioactive Compounds from Carissa spinarum

Steroidal Saponins fromMyriopteron extensumand Their Cytotoxic Activity

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