Evolving Teeth Within a Stable Masticatory Apparatus in Orkney Mice

Renaud, Sabrina; Ledevin, Ronan; Souquet, Louise; Rodrigues, Helder Gomes; Ginot, Samuel; Agret, Sylvie; Julien, Claude; Herrel, Anthony; Hautier, Lionel

doi:10.1007/s11692-018-9459-6

Cited by 14 publications

(18 citation statements)

References 54 publications

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“…We have noticed in a study of Orkney house mouse populations that the presence of the anterior cusp was associated with a decrease in overall cusp complexity, again consistent with overall decreased level of activation (Renaud et al, 2018). In conclusion, our results thus suggest that the two lines of least resistance seen in murine rodents: the anterior elongation of the upper molar, and the variation in shape seen in both molars are developmentally coupled by a common setting of the activation/inhibition balance.…”

Section: Discussionsupporting

confidence: 82%

“…In particular, it evolved independently in many Mus (Mus) musculus domesticus island populations (e.g. on several Corsican islands, Marion Island (Renaud et al, 2011), Orkney islands (Ledevin et al, 2016;Renaud et al, 2018), as well as on Kerguelen and the Canary islands, S. Renaud, (Ledevin et al, 2016)). Interestingly, anterior elongation is found associated with increased body size in domestic mouse populations (Renaud et al 2011), being trapped on island (and following "Foster's rule", or "island rule" where small mammals become gigantic) or in cold environments.…”

Section: Introductionmentioning

confidence: 99%

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Developmental variability channels mouse molar evolution

Hayden

Lochovska

Sémon

et al. 2020

eLife

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Do developmental systems preferentially produce certain types of variation that orient phenotypic evolution along preferred directions? At different scales, from the intra-population to the interspecific, the murine first upper molar shows repeated anterior elongation. Using a novel quantitative approach to compare the development of two mouse strains with short or long molars, we identified temporal, spatial and functional differences in tooth signaling center activity, that arise from differential tuning of the activation-inhibition mechanisms underlying tooth patterning. By tracing their fate, we could explain why only the upper first molar reacts via elongation of its anterior part. Despite a lack of genetic variation, individuals of the elongated strain varied in tooth length and the temporal dynamics of their signaling centers, highlighting the intrinsic instability of the upper molar developmental system. Collectively, these results reveal the variational properties of murine molar development that drive morphological evolution along a line of least resistance.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Developmental variability channels mouse molar evolution

Hayden

Lochovska

Sémon

et al. 2020

eLife

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“…Rats from Micronesia and Polynesia were introduced last, and have thus spent the shortest time on their respective islands. This confirms the notion of rapid evolution in alien rodents on islands (e.g., Berry, 1964;Pergams & Ashley, 2001;Jones, Chown & Gaston, 2003;Cucchi et al, 2014;Ledevin et al, 2016;Renaud et al, 2018), where often one or two centuries are already sufficient to evolve considerably different skull shapes. Also, it indicates that this short span evolution mainly concerns body size evolution without restructuring.…”

Section: Discussionsupporting

confidence: 82%

Size matters: micro-evolution in Polynesian rats highlights body size changes as initial stage in evolution

Geer

2020

PeerJ

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Microevolutionary patterns in populations of introduced rodent species have often been the focus of analytic studies for their potential relevance to understanding vertebrate evolution. The Polynesian rat (Rattus exulans) is an excellent proxy species because of its wide geographic and temporal distribution: its native and introduced combined range spans half the globe and it has been living for at least seven centuries wherever it was introduced. The objective of this study was to assess the effects of long-term isolation (insularity; up to 4,000 years) and geographic variables on skull shape variation using geometric morphometrics. A sample of 513 specimens from 103 islands and four mainland areas was analysed. This study, to my knowledge the first to extensively sample introduced rats, analysed 59 two-dimensional landmarks on the skull. Landmarks were obtained in three separate aspects (dorsal, lateral, ventral skull view). The coordinate data were then subjected to a multivariate ordination analysis (principal components analysis, or PCA), multivariate regressions, and a canonical variates analysis (CVA). Three measures of disparity were evaluated for each view. The results show that introduced Polynesian rats evolve skull shapes that conform to the general mammalian interspecific pattern of cranial evolutionary allometry (CREA), with proportionally longer snouts in larger specimens. In addition, larger skulls are more tubular in shape than the smaller skulls, which are more balloon-shaped with a rounder and wider braincase relative to those of large skulls. This difference is also observed between the sexes (sexual dimorphism), due to the slightly larger average male size. Large, tubular skulls with long snouts are typical for Polynesia and Remote Oceania, where no native mammals occur. The greater disparity of Polynesian rats on mammal species-poor islands (’exulans-only’ region) provides further insight into how diversity may affect diversification through ecological release from predators and competitors.

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“…We note that the narrow morphology of DUHi (lower and upper) molars as compared with the broad, massive morphology of FVB molars is also consistent with decreased levels of activation in this strain. We have noticed in a study of Orkney house mouse populations that the presence of the anterior cusp was associated with a decrease in overall cusp complexity, again consistent with overall decreased level of activation (Renaud et al, 2018). In conclusion, our results thus suggest that the two lines of least resistance seen in murine rodents: the anterior elongation of the upper molar, and the variation in length/breath seen in both molars are developmentally coupled by a common setting of the activation/inhibition balance.…”

Section: Discussionsupporting

confidence: 62%

Developmental variability drives mouse molar evolution along an evolutionary line of least resistance

Hayden

Lochovska

Sémon

et al. 2019

Preprint

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Developmental systems may preferentially produce certain types of variation and, thereby, bias phenotypic evolution. This is a central issue in evolutionary developmental biology, albeit somewhat understudied. Here we focus on the shape of the first upper molar which shows a clear, repeated tendency for anterior elongation at different scales from within mouse populations to between species of the Mus genus. In contrast, the lower molar displays more evolutionary stability. We compared upper and lower molar development of mouse strains representative of this fine variation (DUHi: elongated molars and FVB: short molars). Using a novel quantitative approach to examine small-scale developmental variation, we identified temporal, spatial and functional differences in tooth signaling centers between the two strains, likely due to different tuning of the activation-inhibition mechanisms ruling signaling center patterning. Based on the spatio-temporal dynamics of signaling centers and their lineage tracing, we show an intrinsic difference in the fate of signaling centers between lower and upper jaw of both strains. This can explain why variations in activation-inhibition parameters between strains are turned into anterior elongation in the upper molar only. Finally, although the "elongated" DUHi strain was inbred, first molar elongation was variable in adults, and we found high levels of intra-strain developmental variation in upper molar development. This is consistent with the inherent developmental instability of the upper molar system enabling the morphological variability of the tooth phenotype.In conclusion, we have uncovered developmental properties that underlie the molar's capacity for repeated phenotypic change, or said differently, that underlie a "line of least resistance".By focusing on the developmental basis of fine phenotypic variation, our study also challenges some common assumptions and practices in developmental and evolutionary developmental biology.

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Evolving Teeth Within a Stable Masticatory Apparatus in Orkney Mice

Cited by 14 publications

References 54 publications

Developmental variability channels mouse molar evolution

Developmental variability channels mouse molar evolution

Size matters: micro-evolution in Polynesian rats highlights body size changes as initial stage in evolution

Developmental variability drives mouse molar evolution along an evolutionary line of least resistance

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