Objectives: to evaluate the effect of piezoelectric surgery in comparison with the conventional surgical saw regarding clinical and histological parameters. Patients and Methods: 11 patients were included in a prospective comparative study to evaluate the effect of piezoelectric device in maxillary orthognathic surgery in comparison with the conventional regarding clinical and histological parameters. Assessment in this study included intraoperative bleeding, osteotomy time, postoperative facial edema, pain, and osteotomy site coagulative bone necrosis. Results: Coagulative bone necrosis comparison showed a statistically significant higher mean in the saw group compared to the peizotome group with p-value (p<0.001). There was a statistically significant increase of blood loss in saw group compared to peizotome group p-value (p=0.006). regarding osteotomy time there were a statistically significant increase in peizotome group compared to saw group p-value (p<0.001). There were no significant difference in facial swelling between both groups.A significant differences in postoperative pain between both groups at 1st , 2nd 3rd and 4th week postoperatively (P.value = 0.006), (P.value = 0.001), (P.value = 0.005) and (P.value= 0.002) in contrary to the 1st day postoperative follow up. Conclusion: Piezoelectric osteotomy device is effectively able to carry out osteotomy, more safe than surgical saw resulting in less blood loss in maxillary orthognathic surgery, less post-operative pain sensation, and obviously decrease marginal bone necrosis than saw. In spite, the saw is superior to piezo in osteotomy time, piezoelectric surgery provide the faster bone repair.