Evolving or immutable - phase I solid tumor trials in the era of precision oncology
Shannon S. Stockton,
G. Dan Ayers,
Cody Lee
et al.
Abstract:In the era of precision oncology (PO), systemic therapies for patients (pts) with solid tumors have shifted from chemotherapy (CT) to targeted therapy (TT) and immunotherapy (IO). This systematic survey describes features of trials enrolling between 2010 and 2020, focusing on inclusion criteria, type of dose escalation scheme (DES) utilized, and use of expansion cohorts (ECs). A literature search identified phase I studies in adults with solid tumors published January 1, 2000– December 31, 2020 from 12 journal… Show more
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