Evolving interplay between natural products and gut microbiota

Jiang, Zheng‐Meng; Li, Shang-Zhen; Yang, Xing Sheng; Liu, E‐Hu

doi:10.1016/j.ejphar.2023.175557

Cited by 5 publications

(4 citation statements)

References 217 publications

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“…Gut microbes are closely related to the host's nutrient absorption and metabolism and can help the host perform specific physiological and biochemical functions (Zhang et al, 2023 ). Fecal samples are a non-invasive and sustainable method for observing animal gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

The study on the impact of sex on the structure of gut microbiota of bamboo rats in China

Gan,

Wu,

Dong

et al. 2023

Front. Microbiol.

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IntroductionBamboo rats are rodents that eat bamboo, and their robust capacity for bamboo digestion is directly correlated with their gut flora. Chinese bamboo rat (Rhizomys sinensis) is a common bamboo rat in Chinese central and southern regions. As a single-stomach mammal, bamboo rats are a famous specificity bamboo-eating animal and their intestinal microbial composition may also play a key role in the digestion of cellulose and lignin. So, the gut microbiota of bamboo rat may play an important role in the adaptation of bamboo rats for digesting lignocellulose-based diet.MethodsTo study the microbiome differences of bamboo rats from different sexes, the microbial genomic DNA was extracted from each fecal sample and the V4 region of 16S rRNA genes was amplified and sequencing on an IlluminaHiSeq6000 platform. The operational taxonomic units (OTUs) were classified, the OTUs in different sexes was identified and compared at phylum and genus levels. For isolation and screening of cellulose degradation bacteria from bamboo rats, fresh feces from randomly selected bamboo rats were collected and used for the isolation and screening of cellulose degradation bacteria using Luria Bertani (LB) Agar medium containing Carboxymethyl cellulose. The cellulase activity, biochemical characterization and phylogenetic analysis of the purified bacteria strains were characterized.Results and discussionA total of 3,833 OTUs were classified. The total microbial diversity detected in the female and male rats was 3,049 OTUs and 3,452 OTUs, respectively. The Shannon index revealed significant differences between the two groups (p < 0.05), though they were all captive and had the same feeding conditions. At the phylum level, Firmicutes, Bacteroidota, and Proteobacteria were prominent in the microbial community. At the genus level, the microbial community was dominated by Lachnospiraceae, Lactobacillus, Bacteroides, and Prevotella, but there was a significant difference between the two groups of bamboo rats; ~90 bacteria genus in the female group was significantly higher than the male group. Among them, Bacteroides, Colidextribacter, and Oscillibacter were significantly higher genera, and the genera of Lachnoclostridium, Oscillibacter, and Papillibacter had the highest FC value among the male and female bamboo rats. The KEGG function annotation and different pathways analysis revealed that membrane transport, carbohydrate metabolism, and amino acid metabolism were the most enriched metabolic pathways in the two groups, and multiple sugar transport system permease protein (K02025 and K02026), RNA polymerase sigma-70 factor (K03088), and ATP-binding cassette (K06147) were the three different KEGG pathways (p < 0.05). Two cellulose degradation bacteria strains—Bacillus subtilis and Enterococcus faecalis—were isolated and characterized from the feces of bamboo rats.

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Section: Discussionmentioning

confidence: 99%

The study on the impact of sex on the structure of gut microbiota of bamboo rats in China

Gan,

Wu,

Dong

et al. 2023

Front. Microbiol.

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“…For instance, 3-hydroxyphenyl, a hydrolytic metabolite of quercetin, has been shown to effectively lower arterial blood pressure and induce vascular relaxation in rats ( Najmanová et al., 2016 ). Ginsenosides derived from steroids have demonstrated protective effects against atherosclerosis, with this protection being attributed to intestinal microbiome hydrolases ( Zhang N-N. et al., 2023 ). The microbiome hydrolysates Rb1, Rg2, Rg3, and compound K have been found to alleviate atherosclerosis through various pathways.…”

Section: Interactions Between Hydrolases and Natural Product Drugs Af...mentioning

confidence: 99%

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism

He,

Liu,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs. Despite the significance of natural product drugs in the field of oral medications, there is a lack of research on the regulatory interplay between gut microbiome-derived hydrolases and these drugs. This review delves into the interaction between intestinal microbiome-derived hydrolases and natural product drugs metabolism from three key perspectives. Firstly, it examines the impact of glycoside hydrolases, amide hydrolases, carboxylesterase, bile salt hydrolases, and epoxide hydrolase on the structure of natural products. Secondly, it explores how natural product drugs influence microbiome-derived hydrolases. Lastly, it analyzes the impact of interactions between hydrolases and natural products on disease development and the challenges in developing microbial-derived enzymes. The overarching goal of this review is to lay a solid theoretical foundation for the advancement of research and development in new natural product drugs and personalized treatment.

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“…Many research studies have indicated that only some plant natural products are absorbed in the small intestine, while most of these products reach the colon, where the composition of the gut microbiota can be affected, facilitating the metabolism of the microbiota and alleviating MAFLD. Recent studies have suggested that plant natural products may exert their hypolipidemic and hepatoprotective effects by altering the structure of and metabolite production by the gut microbiota ( Zhang N-N. et al., 2023 ). However, the effects of plant natural products on MAFLD and the underlying mechanisms are also poorly understood and need to be further clarified, especially given the data from the last five years.…”

Section: Introductionmentioning

confidence: 99%

Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

Cai,

Song,

et al. 2024

Front. Cell. Infect. Microbiol.

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Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease characterized by the excessive accumulation of fat in hepatocytes. However, due to the complex pathogenesis of MAFLD, there are no officially approved drugs for treatment. Therefore, there is an urgent need to find safe and effective anti-MAFLD drugs. Recently, the relationship between the gut microbiota and MAFLD has been widely recognized, and treating MAFLD by regulating the gut microbiota may be a new therapeutic strategy. Natural products, especially plant natural products, have attracted much attention in the treatment of MAFLD due to their multiple targets and pathways and few side effects. Moreover, the structure and function of the gut microbiota can be influenced by exposure to plant natural products. However, the effects of plant natural products on MAFLD through targeting of the gut microbiota and the underlying mechanisms are poorly understood. Based on the above information and to address the potential therapeutic role of plant natural products in MAFLD, we systematically summarize the effects and mechanisms of action of plant natural products in the prevention and treatment of MAFLD through targeting of the gut microbiota. This narrative review provides feasible ideas for further exploration of safer and more effective natural drugs for the prevention and treatment of MAFLD.

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Evolving interplay between natural products and gut microbiota

Cited by 5 publications

References 217 publications

The study on the impact of sex on the structure of gut microbiota of bamboo rats in China

The study on the impact of sex on the structure of gut microbiota of bamboo rats in China

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism

Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

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