Evolving Importance of Diffusion-Weighted Magnetic Resonance Imaging in Lymphoma

Kwee, Thomas C.; Basu, Sandip; Torigian, Drew A.; Nievelstein, Rutger A.J.; Alavi, Abass

doi:10.1016/j.cpet.2011.11.001

Cited by 14 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The detection rate of transverse DWI sequences was only 34%. DWI relies on detection of the random brownian motion of water molecules in the respective tissues (27). The assessment of DWI in our study probably underestimates their true potential since anatomic boundaries and morphologic landmarks are hardly visible in DWI.…”

Section: Discussionmentioning

confidence: 76%

Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

Georgi

Stoevesandt²,

Kurch

et al. 2022

J Nucl Med

View full text Add to dashboard Cite

F-FDG PET/MRI might be the diagnostic method of choice for Hodgkin lymphoma patients, as it combines significant metabolic information from PET with excellent soft-tissue contrast from MRI and avoids radiation exposure from CT. However, a major issue is longer examination times than for PET/CT, especially for younger children needing anesthesia. Thus, a targeted selection of suitable whole-body MRI sequences is important to optimize the PET/MRI workflow. Methods: The initial PET/MRI scans of 84 EuroNet-PHL-C2 study patients from 13 international PET centers were evaluated. In each available MRI sequence, 5 PET-positive lymph nodes were assessed. If extranodal involvement occurred, 2 splenic lesions, 2 skeletal lesions, and 2 lung lesions were also assessed. A detection rate was calculated dividing the number of visible, anatomically assignable, and measurable lesions in the respective MRI sequence by the total number of lesions. Results: Relaxation time-weighted (T2w) transverse sequences with fat saturation (fs) yielded the best result, with detection rates of 95% for nodal lesions, 62% for splenic lesions, 94% for skeletal lesions, and 83% for lung lesions, followed by T2w transverse sequences without fs (86%, 49%, 16%, and 59%, respectively) and longitudinal relaxation timeweighted contrast-enhanced transverse sequences with fs (74%, 35%, 57%, and 55%, respectively). Conclusion: T2w transverse sequences with fs yielded the highest detection rates and are well suited for accurate whole-body PET/MRI in lymphoma patients. There is no evidence to recommend the use of contrast agents.

show abstract

Section: Discussionmentioning

confidence: 76%

Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

Georgi

Stoevesandt²,

Kurch

et al. 2022

J Nucl Med

View full text Add to dashboard Cite

show abstract

“…However, there is no agreement on DWI parameters ( b values) to be used. Lymphoma is characterized by high cellularity and elevated nuclear‐to‐cytoplasm ratio leading to restricted diffusion of water molecules than in normal tissues, thus producing high signal intensity on DWI and low ADC values, which help to easily identify the sites of disease . Gradient‐echo Dixon sequence has been more and more used.…”

Section: Wb‐mri: Main Aspects Of Its Use In Lymphomamentioning

confidence: 99%

Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art

Albano

Bruno

Patti

et al. 2019

Hematological Oncology

View full text Add to dashboard Cite

The improvements in magnetic resonance imaging (MRI) technology and the concern related to the increased cancer risk in patients with lymphoma, also due to radiation exposure associated with imaging examinations, have led to the introduction of whole‐body MRI (WB‐MRI) as a radiation‐free alternative to standard imaging procedures. WB‐MRI seems a less histology‐dependent functional imaging test than 18F‐fluorodeoxyglucose‐positron emission tomography/CT (18F‐FDG‐PET/CT). In patients with FDG‐avid lymphomas, such as diffuse large B‐cell lymphoma (DLBCL) and Hodgkin lymphoma (HL), 18F‐FDG‐PET/CT remains the imaging reference standard for staging, with WB‐MRI potentially being a complementary modality that could replace CT, especially in young patients. On the other hand, WB‐MRI is a valuable imaging procedure for lymphoma surveillance and in lymphomas with variable/low FDG avidity and nonfollicular indolent lymphomas. The aim of this paper is to discuss the current state of the art of WB‐MRI in lymphoma by evaluating its diagnostic performance in different lymphoma subtypes: Hodgkin, aggressive, and indolent lymphomas.

show abstract

“… 13 , 14 In malignant lymphoma, MRI demonstrates T2 high intensity with Gd enhancement and a decrease in ADC. 15 , 16 For the diagnosis of uterine relapse of ALL, MRI was effective in two previously reported cases and ours, and its common findings, i.e., T2 high intensity with Gd enhancement and the marked decrease in ADC, may be useful to differentiate the lesion from primary uterine cancer.…”

Section: Discussionmentioning

confidence: 58%

Uterine relapse of Philadelphia chromosome-negative acute lymphoblastic leukemia

Kawano

Maeda²,

Kawano

et al. 2020

J Clin Exp Hematopathol

View full text Add to dashboard Cite

The relapse of acute lymphoblastic leukemia (ALL) usually involves the bone marrow, with the central nervous system being the most frequent extramedullary site. The relapse of ALL in the female genital organs, particularly the uterus, is markedly rare. We report such a patient who developed relapse in the bone marrow and uterus. The uterine lesion, which presented as abnormal uterine bleeding, consisted of a mass on MRI and proliferation of ALL cells on histology. MRI revealed a heterogeneous high-intensity mass (T2-WI/D-WI) with a diameter of 6.8 cm, a notable decrease in the apparent diffusion coefficient (ADC), and mild enhancement by contrast enhancement study. Histological findings of the uterine cervix demonstrated the infiltration of ALL. The patient achieved remission by allogeneic haplo-identical hematopoietic stem-cell transplantation, but died of complications of the transplantation. This case suggested that attention should be paid to the uterus as a site of extramedullary relapse. In addition, abnormal uterine bleeding, which is a common sign of hormonal imbalance and hormone replacement therapy after chemotherapy, may be an initial sign of extramedullary recurrence. To confirm uterine relapse as an intractable disease, the accumulation of more cases is required.

show abstract

Evolving Importance of Diffusion-Weighted Magnetic Resonance Imaging in Lymphoma

Cited by 14 publications

References 46 publications

Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art

Uterine relapse of Philadelphia chromosome-negative acute lymphoblastic leukemia

Contact Info

Product

Resources

About