Evolving application of biomimetic nanostructured hydroxyapatite

Roveri, Norberto; Iafisco, Michele

doi:10.2147/nsa.s9038

Cited by 66 publications

(60 citation statements)

References 170 publications

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“…For example, Acticoat™ and Algisite™ are patches for wound dressing based on antibacterial silver nanoparticles (Smith and Nephew, 2014). For products loaded instead with calcium phosphate or hydroxyapatite (HA) nanoparticles, Ostim™[Osartis, Germany (Doessel and Schlegel, 2010)], Vitoss™[Orthovita, USA (Kurien et al, 2013)], and NanOss™[Angstrom Medica, USA (Roveri and Iafisco, 2010)] can be mentioned, which have been launched in recent years as synthetic bone graft substitutes. For specific dental applications, some HA coatings of dental implants have also been introduced [e.g., Spline Twist MP-1™ by Zimmer (2014), USA], but generally without much success probably due to delamination effects at the interface with the Ti alloy implant core.…”

Section: Implant Surface Functionalizationmentioning

confidence: 99%

Dentistry on the Bridge to Nanoscience and Nanotechnology

Salerno

Diaspro

2015

Front. Mater.

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Dentistry is the area of medical sciences that is most resistant to the introduction of the novel methods arisen from the development of nanoscience and nanotechnology in the last 20 years. Without moving on to science-fiction-like views pointing to times far ahead in the future, we show that the available nanoscale devices and processes of current science and technology, partly inherited from the areas of microscopy and microelectronics, have already proven to be useful for research and development in different fields of dental research. To this goal, we review some results obtained in the last few years at our Institute in the area of dental materials and their characterization, which showed successful application of our background in microscopy and nanoengineering.Keywords: dental materials, microscopy, surface roughness, nanofabrication, resin composites, implants THE BROAD SCOPE OF DENTISTRYDentistry is considered to be a branch of medicine, such as orthopedics or physiology or neurology. In fact, while based on common foundations of medicine, dentistry is a large stand-alone area, which has its own grasps to the different fields mentioned above (American Dental Association, 2014). For example, topics of periodontal ligament health and dental implant osteointegration clearly relate to a peculiar "dental orthopedics"; the fact that teeth are not a mineralized appendix but rather a living organ in a living environment (gingiva, oral liquids) involves a specific "dental physiology"; the sensitivity of the living tooth, in connection with the pulp and related nerves, can be associated to a possible "dental neurology." Indeed, the oral environment, which is the place where dental functions are operated, is one of the most complex ones in the human body.As a result, within the dental area several specialized disciplines exist (see Figure 1). Conservative dentistry aims to maintain the original denture and largely overlaps with restorative dentistry, the latter encompassing prosthodontics, periodontics, and endodontics. Prosthodontics (or prosthetic dentistry) is required in case of massive irreversible tooth damage that cannot be fixed with simple resin composite filling, and requires the use of prosthesis for teeth, namely crowns, bridges, and even whole dentures. Periodontics (or periodontology) addresses the diseases of the periodontum, i.e., the teeth ligaments. Endodontics focuses on therapy of the root canals and connected pulp diseases. Oral surgery relates to the extraction of teeth that cannot be saved anymore and should be replaced by implants, and is usually combined with maxillo-facial surgery, extending the treated area around the denture. Prosthodontics, periodontics, and surgery correlate to implantology, which deals with the installation of dental implants. Orthodontics concerns the alignment and straightening of teeth, as well as fixing midface and mandibular growth issues. Pedodontics (or pediatric dentistry) relates to the specific dental issues of children's temporary dentures. Of course, oral...

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Section: Implant Surface Functionalizationmentioning

confidence: 99%

Dentistry on the Bridge to Nanoscience and Nanotechnology

Salerno

Diaspro

2015

Front. Mater.

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“…Biomimicry for the synthesis of biomaterials can be performed at distinct levels according to the composition, structure, morphology and physicochemical properties of the synthetic material. 4,5 A m o n g t h e b i o m a t e r i a l s , h y d r o x y a p a t i t e (Ca 10 (PO 4 ) 6 (OH) 2 , HA) has been studied and applied in several biomedical research fields, due to its similarity with the mineral constituents of human bones and teeth. 6 Synthetic HA nanoparticles exhibit good biocompatibility, bioactivity and osteoinducibility.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Recent research focuses on overcoming limitations of calcium phosphates and HA ceramics such as low bioresorbability, low surface area and low bioreactivity, and the improvement of their biological properties. 4,5 The major mineral makeup of bone are homogeneous plate-like HA crystals with lengths of 15-30 nm and diameters of 30-50 nm, and enamel and dentin are beadshaped HA crystals with diameters of 25-100 nm and lengths of 100 nm to microns. The study of biomineralization and biomimetic assembly involves the search for an advanced method so that the synthesis of HA nanocrystals can be controlled with precision.…”

Section: Introductionmentioning

confidence: 99%

“…The study of biomineralization and biomimetic assembly involves the search for an advanced method so that the synthesis of HA nanocrystals can be controlled with precision. 4,12,13 With nanotechnology, it is possible to synthesize inorganic crystals with nanometric dimensions, characterized by high surface area, shape control and structural organization that increases crystalline bioreactivity. For the optimization of the biomedical applications of biomimetic HA, its chemical and physical characteristics such as size, porosity, morphology and surface properties must be adapted according to the application.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Optimization of Colloidal Hydroxyapatite Nanoparticles by Hydrothermal Processes

Arantes¹,

Coimbra²,

Cristovan³

et al. 2018

J. Braz. Chem. Soc.

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This paper reports an optimized, simple, fast and inexpensive method for hydroxyapatite (HA) nanoparticle synthesis. Through a multivariate statistical analysis using a factorial design with 2 3 resolution, an empirical model was developed which allows control of the shape and size of the HA nanoparticles. This model was used to synthesize HA nanoparticles with sizes between 8 and 600 nm, formed by oriented attachment growth mechanism. The structure was confirmed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) images, which also showed that HA nanoparticles had well-defined nanorod forms and narrow size distributions. It was observed that the model is statistically significant and the main parameter for the growth of crystals in the hydrothermal process was temperature.

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“…4 Due to its microstructure, biocompatibility, and osteoconductivity, nanosized HAp (nanohydroxyapatite, nHAp) has been widely investigated for applications in bone tissue regeneration. 4,[7][8][9] Nevertheless, the low tensile strength and fracture toughness of nHAp limit its application in large bone defects. In this context, the literature has introduced many different approaches to combine nHAp and different forms of carbon in order to enhance the mechanical properties of nHAp without impairing its bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation

Rodrigues¹,

Leite²,

Cavalcanti³

et al. 2016

IJN

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Nanohydroxyapatite (nHAp) is an emergent bioceramic that shows similar chemical and crystallographic properties as the mineral phase present in bone. However, nHAp presents low fracture toughness and tensile strength, limiting its application in bone tissue engineering. Conversely, multi-walled carbon nanotubes (MWCNTs) have been widely used for composite applications due to their excellent mechanical and physicochemical properties, although their hydrophobicity usually impairs some applications. To improve MWCNT wettability, oxygen plasma etching has been applied to promote MWCNT exfoliation and oxidation and to produce graphene oxide (GO) at the end of the tips. Here, we prepared a series of nHAp/MWCNT-GO nanocomposites aimed at producing materials that combine similar bone characteristics (nHAp) with high mechanical strength (MWCNT-GO). After MWCNT production and functionalization to produce MWCNT-GO, ultrasonic irradiation was employed to precipitate nHAp onto the MWCNT-GO scaffolds (at 1–3 wt%). We employed various techniques to characterize the nanocomposites, including transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetry, and gas adsorption (the Brunauer–Emmett–Teller method). We used simulated body fluid to evaluate their bioactivity and human osteoblasts (bone-forming cells) to evaluate cytocompatibility. We also investigated their bactericidal effect against Staphylococcus aureus and Escherichia coli . TEM analysis revealed homogeneous distributions of nHAp crystal grains along the MWCNT-GO surfaces. All nanocomposites were proved to be bioactive, since carbonated nHAp was found after 21 days in simulated body fluid. All nanocomposites showed potential for biomedical applications with no cytotoxicity toward osteoblasts and impressively demonstrated a bactericidal effect without the use of antibiotics. All of the aforementioned properties make these materials very attractive for bone tissue engineering applications, either as a matrix or as a reinforcement material for numerous polymeric nanocomposites.

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Evolving application of biomimetic nanostructured hydroxyapatite

Cited by 66 publications

References 170 publications

Dentistry on the Bridge to Nanoscience and Nanotechnology

Dentistry on the Bridge to Nanoscience and Nanotechnology

Synthesis and Optimization of Colloidal Hydroxyapatite Nanoparticles by Hydrothermal Processes

Graphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation

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