Evolved resistance to PCB- and PAH-induced cardiac teratogenesis, and reduced CYP1A activity in Gulf killifish (Fundulus grandis) populations from the Houston Ship Channel, Texas

Oziolor, Elias M.; Bigorgne, Emilie; Aguilar, Lissette; Usenko, Sascha; Matson, Cole W.

doi:10.1016/j.aquatox.2014.03.012

Cited by 61 publications

(35 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because tolerance to some chemicals has evolved independently multiple times (Nacci et al., 2010), powerful comparative methods may be brought to bear. Pollution tolerance has also evolved in populations of their sister species Fundulus grandis (Oziolor, Bigorgne, Aguilar, Usenko, & Matson, 2014). Furthermore, much is known about the molecular mechanisms of action for the major chemical pollutants to which they have adapted, thereby providing a foundation for inferring the function of genes and pathways showing signatures of adaptive divergence.…”

Section: Introduction To the Killifish Story: Rapid Adaptation To Extmentioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

108

102

View full text Add to dashboard Cite

For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the effects of human‐mediated environmental changes, including environmental pollution. Here we review how key features of populations, the characteristics of environmental pollution, and the genetic architecture underlying adaptive traits, may interact to shape the likelihood of evolutionary rescue from pollution. Large populations of Atlantic killifish (Fundulus heteroclitus) persist in some of the most contaminated estuaries of the United States, and killifish studies have provided some of the first insights into the types of genomic changes that enable rapid evolutionary rescue from complexly degraded environments. We describe how selection by industrial pollutants and other stressors has acted on multiple populations of killifish and posit that extreme nucleotide diversity uniquely positions this species for successful evolutionary adaptation. Mechanistic studies have identified some of the genetic underpinnings of adaptation to a well‐studied class of toxic pollutants; however, multiple genetic regions under selection in wild populations seem to reflect more complex responses to diverse native stressors and/or compensatory responses to primary adaptation. The discovery of these pollution‐adapted killifish populations suggests that the evolutionary influence of anthropogenic stressors as selective agents occurs widely. Yet adaptation to chemical pollution in terrestrial and aquatic vertebrate wildlife may rarely be a successful “solution to pollution” because potentially adaptive phenotypes may be complex and incur fitness costs, and therefore be unlikely to evolve quickly enough, especially in species with small population sizes.

show abstract

Section: Introduction To the Killifish Story: Rapid Adaptation To Extmentioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

108

102

View full text Add to dashboard Cite

show abstract

“…Effects such as (i) genome‐wide changes in diversity, (ii) changes in allelic or genotypic frequencies due to contaminant‐mediated selective pressure, (iii) changes in gene flow between populations, and (iv) increased mutation rates (Bickham, 2011) have been used to describe and search for patterns of differentiation. Studies in this field explore a wide range of selective pressures: metals (Xie & Klerks, 2003), polycyclic aromatic hydrocarbons (Mulvey, Newman, Vogelbein, & Unger, 2002; Ownby et al., 2002), polychlorinated biphenyls (Nacci et al., 1999; Oziolor, Bigorgne, Aguilar, Usenko, & Matson, 2014), dioxins and furans (Yuan, Courtenay, Chambers, & Wirgin, 2006), and in addition a variety of organisms (Oziolor, De Schamphelaere, & Matson, 2016a), but mostly focused on aquatic species. Previous reviews in the field focus on evolutionary research in fish (Wirgin & Waldman, 2004), across stressors (Oziolor & Matson, 2015), and the push toward quantitative genetics to link these processes to heritability and fitness of populations (Klerks, Xie, & Levinton, 2011).…”

Section: Principles Of Evolutionary Toxicologymentioning

confidence: 99%

“…Complementary to those, other investigations have focused on the downstream effects on population health and functional differences in adapted populations. These studies have largely focused on aquatic populations, reporting decreased life span in adapted Atlantic tomcod (Dey, Peck, Smith, & Kreamer, 1993), liver neoplasia in adapted killifish (Vogelbein, Fournie, Van Veld, & Huggett, 1990), altered ability to properly develop and induce molecular responses to early developmental exposure in adapted Atlantic (Elskus, Monosson, McElroy, Stegeman, & Woltering, 1999; Nacci et al., 1999) and Gulf (Oziolor et al., 2014) killifish. Quantitative genetic efforts stemming largely from experimental evolutionary toxicology aim to quantify heritability and costs of adaptation to contaminants (Klerks et al., 2011; Xie & Klerks, 2003; Xie & Klerks, 2004).…”

Section: Brief History Of Evolutionary Toxicologymentioning

confidence: 99%

“…It is also known that both basal and maximal induction levels of protein activity among reference populations of F. grandis are very similar (Oziolor et al., 2016b). Additionally, anthropogenic evolution (evolution in response to anthropogenic stressors) has been shown to result in the down‐regulation of both basal and maximum induction levels for this pathway (Oziolor et al., 2014). This recalcitrant AhR pathway in adapted fish populations is regarded as a resistant phenotype.…”

Section: Gene Expression: Phenotypic Plasticity or Transitory Physiolmentioning

confidence: 99%

See 1 more Smart Citation

Evolutionary toxicology in an omics world

Oziolor

Bickham

Matson

2017

Evolutionary Applications

Self Cite

View full text Add to dashboard Cite

Evolutionary toxicology is a young field that has grown rapidly in the past two decades. The potential of this field comes from the ability to link chemical contamination to multigenerational and population‐wide effects in various species. The advancements and rapidly decreasing costs of ‐omic tools are improving the power and resolution of evolutionary toxicology studies. In this manuscript, we aim to address the trajectories and perspectives for conducting evolutionary toxicology studies with ‐omic approaches. We discuss the complementarity of using multiple ‐omic tools (genomics, eDNA, transcriptomics, proteomics, and metabolomics) for utility in understanding the toxicological relevance of adaptive responses in populations. In addition, we discuss phenotypic plasticity and its relevance to transcriptomic studies in toxicology. As evolutionary toxicology grows and expands its capacity to link toxicology with population‐wide end points, we emphasize the applications of such studies in answering questions about ecological and population health, as well as future applicability to regulation. Thus, we aim to emphasize the enormous potential for evolutionary toxicology in an ‐omics world and give perspectives on the directions of future investigations.

show abstract

“…The lipophilic nature of PAHs enables them to freely enter the cell, where they are ligands for the AhR, a cytosolic receptor. Following binding, the ligand-bound AhR translocates to the nucleus and evokes the transcription of a suite of genes that aid in the metabolism of PAHs through biotransformation and elimination from the cell [25] [26].…”

Section: Biological Consequences Of the Deepwater Horizon Oil Spillmentioning

confidence: 99%

Deepwater Horizon Oil Spill as a Case Study for Interdisciplinary Cooperation within Developmental Biology, Environmental Sciences and Physiology

Burggren¹,

Dubansky²,

Roberts³

et al. 2015

WJET

View full text Add to dashboard Cite

The Deepwater Horizon Oil Spill in the USA's Gulf of Mexico created a high degree of exposure of marine organisms to toxic polyaromatic hydrocarbons (PAHs) present in crude oil. To determine the ecological and physiological effects of crude oil on the Gulf of Mexico ecosystem, the Gulf of Mexico Research Initiative created several research consortia to address overreaching questions concerning the biological impacts of the ecology of the Gulf of Mexico that would otherwise be beyond the capabilities of an individual investigator or a small group. One of these consortia, highlighted in this article, is the RECOVER Consortium, which brings together physiologists, developmental biologists, toxicologists and other life scientists to focus on the multifaceted physiological effects of PAHs, especially as they pertain to cardiovascular and metabolic physiology of economically important fish species. Using the Recover Consortium's interdisciplinary approach to revealing the biological impacts of the Deepwater Horizon Oil Spill as a case study, we make the argument for interdisciplinary teams that bring together scientists with different specialties as an efficient way-and perhaps the only way-to unravel highly complex biological effects of marine oil spills.

show abstract

Evolved resistance to PCB- and PAH-induced cardiac teratogenesis, and reduced CYP1A activity in Gulf killifish (Fundulus grandis) populations from the Houston Ship Channel, Texas

Cited by 61 publications

References 42 publications

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Evolutionary toxicology in an omics world

Deepwater Horizon Oil Spill as a Case Study for Interdisciplinary Cooperation within Developmental Biology, Environmental Sciences and Physiology

Contact Info

Product

Resources

About