Evolvability in the context of antibiotic resistance

Abstract

GlossaryBiological system: We here define a biological system to be any biological entity that can be subject to evolution by natural selection. Cryptic genetic variation:Standing genetic variation that has little effect on phenotypic variation under normal conditions, but generates variation under changed conditions. The release of this variation can facilitate (or hamper) adaptation and thus impact evolvability. Developmental bias:The developmental mechanisms underlying a trait can introduce biases in the variation in the phenotype, even if the underlying mutations are unbiased. These biases can be (but need not be) aligned with the direction of selection, in which case they facilitate adaptive evolution. Johansson, F. et al. (2021) Natural selection mediated by seasonal time constraints increases the alignment between evolvability and developmental plasticity. Evolution (N. Y). 75, ,