“…Heat integration of distillation columns has also been discussed in the context of separation system design as far back as 1974 (Rat-hore et al, 1974a,b). Many articles have analyzed the problem of using such tools as branch and bound (Morari and Faith, 1980), evolutionary design (Nath and Motard, 1981;Umeda et al, 1979a,b), thermodynamic availability (Naka et al, 1982), pinch design (Dundorf and Linnhoff, 1982;Linnhoff et al, 1983) and utility bounding (Andrecovich, 1983;Andrecovich and Westerberg, 1985), among others.…”