2004
DOI: 10.1111/j.1432-1033.2004.04199.x
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Evolutionary relationships of the prolyl oligopeptidase family enzymes

Abstract: The prolyl oligopeptidase (POP) family of serine proteases includes prolyl oligopeptidase, dipeptidyl peptidase IV, acylaminoacyl peptidase and oligopeptidase B. The enzymes of this family specifically hydrolyze oligopeptides with less than 30 amino acids. Many of the POP family enzymes have evoked pharmaceutical interest as they have roles in the regulation of peptide hormones and are involved in a variety of diseases such as dementia, trypanosomiasis and type 2 diabetes. In this study we have clarified the e… Show more

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Cited by 86 publications
(82 citation statements)
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“…central glucose sensing | sympathetic nervous system | peripheral hormonal regulation P rolyl endopeptidase (PREP; EC 3.4.21.26) is a highly conserved enzyme (1). In humans and rodents it is highly expressed in the brain (2), including the cortex, striatum, hypothalamus, hippocampus, and amygdala (3)(4)(5)(6).…”
Section: Hypothalamic Prolyl Endopeptidase (Prep) Regulates Pancreatimentioning
confidence: 99%
“…central glucose sensing | sympathetic nervous system | peripheral hormonal regulation P rolyl endopeptidase (PREP; EC 3.4.21.26) is a highly conserved enzyme (1). In humans and rodents it is highly expressed in the brain (2), including the cortex, striatum, hypothalamus, hippocampus, and amygdala (3)(4)(5)(6).…”
Section: Hypothalamic Prolyl Endopeptidase (Prep) Regulates Pancreatimentioning
confidence: 99%
“…3.4.21.26; also called PO, POP, PE) is a serine protease (Venäläinen et al 2004). The primary function of PREP is thought to hydrolyze the Pro-Xaa bond of short peptides (Polgar 1994;Cunningham and O'Connor 1997).…”
Section: Introductionmentioning
confidence: 99%
“…Prolyl oligopeptidase (POP, prolyl endopeptidase (PREP), EC 3.4.21.26) is a serine-type peptidase (family S9 of clan SC) [1,2] which hydrolyzes peptides shorter than 30 amino acids [3]. POP has been characterized from various mammalian and bacterial sources [2] and is widely distributed throughout different organisms [4].…”
Section: Introductionmentioning
confidence: 99%