Evolutionary Quantitative Genetics: How Little Do We Know?

Barton, Nick; Turelli, Michael

doi:10.1146/annurev.ge.23.120189.002005

Cited by 649 publications

(486 citation statements)

References 91 publications

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“…These results suggest that epistasis may be more prevalent than previously considered and the paucity of direct evidence for epistasis on quantitative traits may originate more from lack of statistical power than from the absence of epistasis (but see Shrimpton & Robertson, 1988;Patterson et at., 1991). Nevertheless, the observation that many quantitative traits are normally distributed argues against large influences of nonadditive effects (Barton & Turelli, 1989;Turelli & Barton, 1990). However, the resulting distribution of individual traits may be nearly normal despite underlying epistasis if loci interact to form groups of functionally inter-related loci (Wright, 1932;Moreno, 1994) whose combined effects are themselves additive.…”

Section: Discussionmentioning

confidence: 99%

Nonadditive genetic structuring of morphometric variation in relation to a population bottleneck

Bryant

Meffert

1996

Heredity

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The genetic architectures of four morphometric traits in the housefly, Musca domestica L., were analysed using a paternal half-sib design on a large outbred base population and on two populations each established with two pairs of flies from the base population. By including parents with the offspring in the analysis, phenotypic variance was subdivided into components for additive, dominance, additive-by-additive epistasis and environmental variation. In relation to the nonbottlenecked base population, narrow sense hertitability was lower in the bottlenecked populations, largely because of an increase in the level of the environmental component of variance. Averaged over the four traits in the nonbottlenecked base population, nonadditive components contributed nearly 60 per cent of the phenotypic variance, with more than half of this being attributable to epistasis. Two of the four traits showed reduced additive genetic variance in the bottlenecked lines, whereas two of the traits showed increased additive genetic variance. A major difference in the genetic architecture between traits showing these two disparate bottleneck effects was the presence of epistasis in the nonbottlenecked base population for the traits which showed an increase in the additive component. Overall, there was a significant positive relationship between the initial percentage contribution of epistasis in the base population and the gain in the additive component in the bottleneck lines, as predicted by models incorporating additive-by-additive epistasis.

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Section: Discussionmentioning

confidence: 99%

Nonadditive genetic structuring of morphometric variation in relation to a population bottleneck

Bryant

Meffert

1996

Heredity

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“…These are the traits that will immediately come under directional selection because they are crucial to survival, and the presence of additive genetic variance will permit relatively rapid response to selection. Long-term changes depend on genetic facts about which we know almost nothing (Barton & Turelli, 1989). Even in the case of major gene effects, variation contributed by modifiers will be necessary for selective fine tuning in the short term (Roff, 1986).…”

Section: Pp-pp H-pp H-h H-bb Bb-bbmentioning

confidence: 99%

“…It goes without saying that obtaining these data presents a considerable challenge, as does determining what genetic or environmental mechanisms maintain the genetic variation in the source population in the first place (cf. Barton & Turelli, 1989). Meeting these challenges would go a long way toward allowing us to predict successful invasions and their consequences.…”

Section: Pp-pp H-pp H-h H-bb Bb-bbmentioning

confidence: 99%

The biology of post-invasion events

Carroll

Dingle

1996

Biological Conservation

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“…Specifically, it is important to determine if spatial variation in phenotypic optima coupled with high migration is a viable alternative to mutation-selection balance for maintaining variation in nature (Barton & Turelli, 1989). Additional refinements in the statistical techniques used to relate morphological to molecular F51 may also increase the power of this method.…”

Section: Clinal Selection On Morphology In Drosophila 577mentioning

confidence: 99%

Molecules versus morphology: the detection of selection acting on morphological characters along a cline in Drosophila melanogaster

Long

Singh

1995

Heredity

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This work examines the nature of north-south clinal variation in morphological characters in Drosophila melanogaster. Isofemale lines were established from flies collected along a transect extending from Winnipeg, Manitoba (Canada) to Tampa Bay, Florida (U.S.A.). Offspring from different lines within each location were then cultured under standardized conditions and used to examine phenotypic variation in seven morphological characters along the dine. In addition, allozyme variation at seven polymorphic loci was examined for the same set of clinal populations. Scutellum length and wing length show the strongest clinal trends. Clinal variation is nonmonotomc, with larger flies in the middle latitudes and smaller flies in the north and south. This result contrasts with other studies which have shown monotonic dines. Patterns of population subdivision were different for the different characters. This implies that there are different selective forces acting on the different morphological characters. Based on a comparison of morphological and molecular population subdivision for adjacent populations it is inferred that natural selection is operating to maintain a high level of population subdivision for wing width and the first principal component between one of the sets of populations. A combined approach using molecules and morphology may provide an alternative to retrospective selection analysis for detecting selection in nature.

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Evolutionary Quantitative Genetics: How Little Do We Know?

Cited by 649 publications

References 91 publications

Nonadditive genetic structuring of morphometric variation in relation to a population bottleneck

Nonadditive genetic structuring of morphometric variation in relation to a population bottleneck

The biology of post-invasion events

Molecules versus morphology: the detection of selection acting on morphological characters along a cline in Drosophila melanogaster

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