Evolutionary peculiarities of hematological syndromes and blood diseases from exposure to occupational hazards

Зюбина, Л. Ю.; Panacheva, L. A.; Шпагина, Л. А.; Карева, Н.Н.; Kotova, Olga; Зуева, М. А.; Горобей, А. М.; Kamneva, Natalya

doi:10.31089/1026-9428-2019-1-45-50

Cited by 3 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В процессе своей трудовой деятельности электрогазосварщик подвергается воздействию целого комплекса опасных и вредных производственных факторов физической и химической природы: излучение, сварочный аэрозоль, кроветворной системы на различные воздействия вредных производственных факторов, особенно химической этиологии. Некоторые из химических веществ, содержащихся в аэрозолях, вызывают изменения гемопоэза, другие нарушают синтез порфирина и гема в гемоглобине, третьи -изменение состава гемоглобина и гемолиз [2,12,14,18,22,27,29].…”

unclassified

Influence of Working Conditions on the State of Health and Laboratory Indicators of Employees When Performing Welding Works

Власова,

Абдрахманова,

Масягутова

et al. 2023

Medicine and Health Care Organization

View full text Add to dashboard Cite

В настоящее время профессия сварщика является одной из самых востребованных в различных отраслях промышленности. Цель работы — проанализировать условия труда, показатели здоровья и определить значимость лабораторных исследований, регламентированных в рамках периодических медицинских осмотров для своевременной диагностики изменений в состоянии здоровья электрогазосварщиков, работающих и проживающих на территории Республики Башкортостан. Проведено клинико- диагностическое обследованиеработников-электрогазосварщиков, работающих на предприятиях республики. Рассмотрено влияние вредных производственных факторов: химического, физического и тяжести трудового процесса. Выявлены заболевания костно- мышечной и нервной систем, болезни системы кровообращения, органов дыхания и нейросенсорная тугоухость с признаками воздействия шума. Диагностированы достоверные изменения лабораторных показателей в зависимости от стажа работы и длительности контакта с производственными факторами. Необходимо проведение диспансерного наблюдения данной категории рабочих с разработкой и обоснованием индивидуальных медико- профилактических мероприятий. Currently, the profession of a welder is one of the most sought after in various industries. The purpose of the work is to analyze working conditions, health indicators anddetermine the significance of laboratory tests regulated as part of periodic medical examinations for the timely diagnosis of changes in the health status of electric and gas welders working andliving on the territory of the Republic of Bashkortostan. A clinical and diagnostic examination of workers — electric and gas welders working at the enterprises of the republic was carried out. Theinfluence of harmful production factors is considered: chemical, physical and the severity of the labor process. Diseases of the musculoskeletal and nervous systems, diseases of the circulatorysystem, respiratory organs, and sensorineural hearing loss with signs of noise exposure were identified. Reliable changes in laboratory parameters were diagnosed depending on the length ofservice and the duration of contact with production factors. It is necessary to carry out dispensary observation of this category of workers with the development and justification of individual medical and preventive measures.

show abstract

unclassified

Influence of Working Conditions on the State of Health and Laboratory Indicators of Employees When Performing Welding Works

Власова,

Абдрахманова,

Масягутова

et al. 2023

Medicine and Health Care Organization

View full text Add to dashboard Cite

show abstract

Leukemia risk and the pattern of dose accumulation. Part 1: Characteristics of the study group of the Mayak Production Association personnel

Sosnina

Okatenko

Yurkin

et al. 2020

Radiac. gig. (2008)

View full text Add to dashboard Cite

Results of development of the database “Leukemia in the cohort of workers of the Mayak Production Association employed in 1948-1958” that was developed in the Laboratory of Radiation Epidemiology of Southern Urals Biophysics Institute were presented. The database contains hematological, clinical and dosimetric information for the workers of main plants of the first production facility of Soviet atomic industry employed in the period of production development – 1948-1958. The computer database contains information for two groups of Mayak Production Association workers: main group of workers with leukemia as the main cause of death (n=84) and group of personnel without hematological cancer pathology for comparison (n=300). The comparison group was composed in such a way to allow 3-4 controls of corresponding gender, age of exposure start, accumulated dose of external gamma-exposure to red bone marrow for each leukemia case. Methods of data collection and sources of medical data were described. Characteristics of software developed for the database was presented. The database containing a total of 19593 results of blood tests reflects dynamics of hematological values in atomic facility personnel due to prolonged radiation exposure. The range of accumulated absorbed doses of external gamma-exposure to red bone marrow in the group of personnel with leukemia diagnoses was 0.001-4.96 Gy; average dose for males was 1.24 Gy and 0.61 Gy – for females. Similar range is observed in the group of personnel without leukemia outcomes. Alongside differences in accumulation rates of external radiation exposure doses is evident: in the group of workers with hematological cancer pathology the average period of radiation exposure at production facility was 14.3 years for males and 12.1 years for females; in the comparison group – 20.4 and 13.9 years, respectively. Most leukemia cases were diagnosed in the workers of radiochemical facility (54.8%). Myeloid leukemia prevailed (47.6%) in the leukemia structure; among them acute myeloid leukemia made more than a half of the cases; lymphoid leukemia was diagnosed in 14.3% cases with prevailing role of chronic lymphoid leukemia. Acute and chronic monocytic leukemia were the rarest types of malignant neoplasms of hematopoietic tissue. Possible correlation between hematological values with individual doses of external gamma- and internal alpha-exposure (incorporated Pu-239) distributed over time was stated. The database allows calculating integrated leukocytic indices reflecting response of hemopoietic system to radiation exposure, tracking changes in hemopoiesis in proportion to accumulated dose to red bone marrow, analyzing specific characteristics of rehabilitation of hematological alterations after occupational contact to ionizing radiation is terminated. Information on acute and chronic diseases available for the workers in the database allows excluding non-specific response of hemopoietic system caused by associated pathology. A revision of leukemia risk estimated in the relation to dose rate for personnel exposed to chronic radiation could be regarded as one of perspective trends in using the database.

show abstract

Features of anemia syndrome in women with endometrial hyperplasia working under the influence of organic solvents and depending on obesity

Lisova

Маринкин

Shpagina

et al. 2023

Med. tr. prom. èkol.

View full text Add to dashboard Cite

Introduction. Organic solvents have a hematotoxic effect, which leads to the development of anemia. Endometrial hyperplasia may also be the cause of a decrease in blood hemoglobin levels. The phenotype of anemia in combination of these diseases is still insufficiently studied. Exposure to organic solvents is associated with a carcinogenic risk, while their role in the development of precancerous conditions is little known. The study aims to research the features of anemia in patients with endometrial hyperplasia under the influence of organic solvents and depending on the obesity factor. Materials and methods. The design of the study is a single–center, single-stage observational. The researchers formed 2 groups of women with endometrial hyperplasia confirmed by histological examination, who worked under conditions of exposure to organic solvents (n=140, the main group, 70 of them obese according to WHO criteria) or who had no health risks (n=140, the comparison group, 68 of them obese). The patients of the main group are painters at a machine-building enterprise. Organic solvents concentrations at the workplace air were 1.2–5.0 times above occupational exposure limits, length of service was 21.5 (18; 28) years. Results. Scientists have registered anemia in 72.9% of obese workers, 54.2% of non-obese workers, 33.8% and 25.0% of patients in the comparison group with obesity and normal body weight, respectively, χ2=8.2, p=0.008. In contact with organic solvents, 60.7% of patients had anemia normal- or macrocytic, normal- or hyperchromic, hyporegenerative. In the subgroup of obesity and atypical endometrial hyperplasia, we have watched the minimum values of hemoglobin — 95 (90; 105) g/l and reticulocytes — 1 (0.5; 2), the maximum values of the average erythrocyte volume — 98 (92; 107) fl and the average hemoglobin content in the erythrocyte — 35(34; 38) pg. The researchers have determined the association of this variant of anemia with atypical endometrial hyperplasia by logistic regression, OR 2.51, 95% CI 1.08–5.85, p=0.033. In comparison group, all patients had iron-deficiency anemia. Limitations. The limitations of the study are related to the recruitment of patients in one center. Conclusion. Anemia in women with endometrial hyperplasia in conditions of organic solvents exposure is normo- or hyperchormic, normo- or macrocytic, hyporegenerative, most prominent in patients with obesity, and associated with atypical histological type of the disease. Ethics. The authors have carried out the study in compliance with the Ethical principles of conducting scientific medical research with human participation, set out in the Helsinki Declaration of the World Medical Association and in accordance with the Ethical norms and rules provided for by the Bulletin of the Higher Attestation Commission of the Ministry of Education of Russia No. 3 of 2002 "On the procedure for conducting biomedical research in humans". The study was approved by the Ethics Committee of the Federal State Budgetary Educational Institution of the Russian Ministry of Health.

show abstract

Evolutionary peculiarities of hematological syndromes and blood diseases from exposure to occupational hazards

Cited by 3 publications

References 8 publications

Influence of Working Conditions on the State of Health and Laboratory Indicators of Employees When Performing Welding Works

Influence of Working Conditions on the State of Health and Laboratory Indicators of Employees When Performing Welding Works

Leukemia risk and the pattern of dose accumulation. Part 1: Characteristics of the study group of the Mayak Production Association personnel

Features of anemia syndrome in women with endometrial hyperplasia working under the influence of organic solvents and depending on obesity

Contact Info

Product

Resources

About