Evolutionary Oscillations in Drosophila pseudoobscura

Dobzhansky, Theodosius

doi:10.1007/978-1-4757-0432-7_6

Cited by 44 publications

(35 citation statements)

References 19 publications

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“…This situation is consistent with the stable inversion polymorphisms observed, for example, in natural populations of D. persimilis (Coyne et al 1992) and laboratory populations of D. pseudoobscura (Dobzhansky 1954;Wallace 1968;Ohta 1971). If the fitnesses of alleles involved in local adaptation vary with environmental conditions, as suggested by laboratory experiments on flies (Dobzhansky 1954), then the inversion frequencies could cycle seasonally, as is seen in D. pseudoobscura (Epling et al 1953;Dobzhansky 1971). If the alleles favored in one population (or species) are incompatible with those favored in the other, inversions will show underdominance, as seen in many interspecific crosses (White 1978;King 1993).…”

Section: Discussionsupporting

confidence: 81%

Chromosome Inversions, Local Adaptation and Speciation

2006

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We study the evolution of inversions that capture locally adapted alleles when two populations are exchanging migrants or hybridizing. By suppressing recombination between the loci, a new inversion can spread. Neither drift nor coadaptation between the alleles (epistasis) is needed, so this local adaptation mechanism may apply to a broader range of genetic and demographic situations than alternative hypotheses that have been widely discussed. The mechanism can explain many features observed in inversion systems. It will drive an inversion to high frequency if there is no countervailing force, which could explain fixed differences observed between populations and species. An inversion can be stabilized at an intermediate frequency if it also happens to capture one or more deleterious recessive mutations, which could explain polymorphisms that are common in some species. This polymorphism can cycle in frequency with the changing selective advantage of the locally favored alleles. The mechanism can establish underdominant inversions that decrease heterokaryotype fitness by several percent if the cause of fitness loss is structural, while if the cause is genic there is no limit to the strength of underdominance that can result. The mechanism is expected to cause loci responsible for adaptive species-specific differences to map to inversions, as seen in recent QTL studies. We discuss data that support the hypothesis, review other mechanisms for inversion evolution, and suggest possible tests.

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Section: Discussionsupporting

confidence: 81%

Chromosome Inversions, Local Adaptation and Speciation

2006

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“…While there is still an active debate over the relatively recent data on enzyme polymorphisms (see the reviews by Wright, 1978;and Harris, 1980), the maintenance of chromosomal polymorphisms has from the earliest days (Wright and Dobzhansky, 1946) been less controversial. The case for selection acting on chromosomal inversions has been consistently more convincing (da Cunha, 1955;Lewontin and White, 1960;Dobzhansky, 1971;Lewontin, 1974;Anderson et a!., 1975). Here we report data on an enzyme polymorphism that is known to be very tightly associated with a chromosomal inversion.…”

Section: Introductionmentioning

confidence: 55%

Genetic variation at the alcohol dehydrogenase locus in natural populations of the seaweed fly, Coelopa frigida

et al. 1982

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SUMMARYSamples of the seaweed fly, Coelopa frigida, from six populations widely spaced around the English coast were collected during 1974-76 and again in 1979-80. Gene frequencies at the Alcohol dehydrogenase (Ad/i) locus were found not to vary significantly between sites, nor over the five year period of their study. Genotype distributions are compared with Hardy-Weinberg expectations and show consistent, mostly significant, differences.These results are interpreted in the light of an association between the Adh locus and a chromosomal inversion polymorphism. It is argued that the remarkable geographical uniformity must indicate the presence of strong selection, probably taking the form of heterokaryotypic advantage.

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“…Most inversions have many and varied phenotypic effects, and are subject to selection in many ways (Dobzhansky, 1970(Dobzhansky, , 1971. It is essential to study the contributions of genic and karyotypic effects to selection on a wider range of characters and in a wider range of species before making generalisations about the way in which inversion polymorphisms are maintained.…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal inversion polymorphisms are often subject to strong selection pressures despite the fact that the only direct effects of the inversion are a change in gene order, and suppression of recombination in heterozygotes (Dobzhansky, 1971).…”

Section: Introductionmentioning

confidence: 99%

Genie and karyotypic selection on an inversion polymorphism in the seaweed fly, Coelopa frigida

Butlin

Day

1985

Heredity

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The seaweed fly, Coelopa frigida, is polymorphic for an inversion on chromosome I. Heterozygotes show higher viability than either homozygote. A series of crosses between lines derived from two geographically distant populations indicates that a significant component of selection is due to the deleterious effects of recessive alleles. Selection at the karyotypic level, if present, is relatively weak.

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Evolutionary Oscillations in Drosophila pseudoobscura

Cited by 44 publications

References 19 publications

Chromosome Inversions, Local Adaptation and Speciation

Chromosome Inversions, Local Adaptation and Speciation

Genetic variation at the alcohol dehydrogenase locus in natural populations of the seaweed fly, Coelopa frigida

Genie and karyotypic selection on an inversion polymorphism in the seaweed fly, Coelopa frigida

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