Evolutionary Origins of Notch Signaling in Early Development

Shi, Shaolin; Stanley, Pamela

doi:10.4161/cc.5.3.2396

Cited by 24 publications

(23 citation statements)

References 40 publications

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“…These observations are consistent with a recent report demonstrating that whereas forced activation of NOTCH signalling in pre-implantation embryos can influence the segregation of the trophectoderm lineage, it does not prevent the formation of morphologically normal blastocysts at E3.5 (Rayon et al, 2014). Together with previous reports showing normal development up to E8.0 of embryos lacking maternal and zygotic expression of key components of the NOTCH pathway (Shi and Stanley, 2006;Souilhol et al, 2006), our results demonstrate that the NOTCH signalling pathway is not a crucial regulator of mouse embryonic development before gastrulation.…”

Section: Discussionsupporting

confidence: 82%

“…Nevertheless, they are indistinguishable from wild-type embryos at E8.0, by which stage all three germ layers have formed (reviewed by Yoon and Gaiano, 2005). Moreover, mutant embryos lacking maternal and zygotic RBPJ or O-fucosyltransferase 1 (POFUT1), both essential components of the canonical NOTCH signalling pathway, develop normally until E8.0 (Shi and Stanley, 2006;Souilhol et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…The NOTCH pathway has been shown to influence cell fate choices leading to the formation of germ layers and the specification of distinct embryonic lineages in various organisms such as C. elegans, sea urchin, zebrafish and Xenopus (Acosta et al, 2011;Revinski et al, 2010;Sethi et al, 2012; reviewed by Shi and Stanley, 2006). In the mouse embryo, the earliest developmental event regulated by NOTCH signalling, in collaboration with the HIPPO pathway, is the formation, before implantation, of an extra-embryonic lineage, the trophectoderm (Rayon et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo

et al. 2015

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NOTCH signalling is an evolutionarily conserved pathway involved in intercellular communication essential for cell fate choices during development. Although dispensable for early aspects of mouse development, canonical RBPJ-dependent NOTCH signalling has been shown to influence lineage commitment during embryonic stem cell (ESC) differentiation. NOTCH activation in ESCs promotes the acquisition of a neural fate, whereas its suppression favours their differentiation into cardiomyocytes. This suggests that NOTCH signalling is implicated in the acquisition of distinct embryonic fates at early stages of mammalian development. In order to investigate in vivo such a role for NOTCH signalling in shaping cell fate specification, we use genetic approaches to constitutively activate the NOTCH pathway in the mouse embryo. Early embryonic development, including the establishment of anterior-posterior polarity, is not perturbed by forced NOTCH activation. By contrast, widespread NOTCH activity in the epiblast triggers dramatic gastrulation defects. These are fully rescued in a RBPJ-deficient background. Epiblast-specific NOTCH activation induces acquisition of neurectoderm identity and disrupts the formation of specific mesodermal precursors including the derivatives of the anterior primitive streak, the mouse organiser. In addition, we show that forced NOTCH activation results in misregulation of NODAL signalling, a major determinant of early embryonic patterning. Our study reveals a previously unidentified role for canonical NOTCH signalling during mammalian gastrulation. It also exemplifies how in vivo studies can shed light on the mechanisms underlying cell fate specification during in vitro directed differentiation.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo

et al. 2015

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“…114 In fact, it is more ancient than previously thought, as EST analyses have revealed the presence of Notch receptors and signaling components (as well as the presence of the Wnt and Hedgehog pathways) in a coral and a sea anemone (Acropora millepora and Nematostella vectensis; Cnidaria, Class Anthozoa) 115 and also in Hydra (Hydra magnipapillata; Cnidaria, Class Hydrozoa). 116 EST sequence similarities have further suggested that Notch may be present even in sponges, but confirmation is required.…”

Section: Speculations: a Joker In A Deck Of Cardsmentioning

confidence: 99%

Notch, Myc and Breast Cancer

Efstratiadis

Szabolcs²,

Klinakis³

2007

Cell Cycle

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“…Elle est fréquemment impliquée dans des choix de différenciations cellulaires via le processus d'inhibition latérale qui limite la propagation d'un type de diffé-renciation ou via l'induction latérale qui homogénéise les choix de destinées au sein d'une population. Il n'est alors pas étonnant de constater que la voie Notch régule plusieurs aspects importants du développement précoce chez des espèces comme le nématode ou la drosophile [4]. La situation est en apparence différente chez les mammifères, où pendant longtemps, aucun lien entre la voie Notch et le développement pré-implantatoire n'a été établi.…”

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