Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation 2015
DOI: 10.1145/2739480.2754640
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Evolutionary Optimization of Cancer Treatments in a Cancer Stem Cell Context

Abstract: We used evolutionary computing for optimizing cancer treatments taking into account the presence and effects of cancer stem cells. We used a cellular automaton to model tumor growth at cellular level, based on the presence of the main cancer hallmarks in the cells. The cellular automaton allows the study of the emergent behavior of the multicellular system evolution in different scenarios defined by the predominance of the different hallmarks. When cancer stem cells (CSCs) are modeled, the multicellular system… Show more

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Cited by 3 publications
(2 citation statements)
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“…In this study, we extend the approach to obtain blending and sampling operators that optimize joint migration inversion (JMI) results. Owing to its ability to manage optimization problems with non-convexity, non-differentiability, the existence of many local minima and large problem space, GAs have successfully been implemented in various application domains (Monteagudo and Santos 2015;Perez-Liebana et al 2015;Bak, Rask and Risi 2016;Davies et al 2016;Scirea et al 2016). However, a standard GA inherently and inevitably needs to evaluate all the solutions to obtain their objective-function values.…”
Section: S U R V E Y -P a R A M E T E R U P D A T Ementioning
confidence: 99%
“…In this study, we extend the approach to obtain blending and sampling operators that optimize joint migration inversion (JMI) results. Owing to its ability to manage optimization problems with non-convexity, non-differentiability, the existence of many local minima and large problem space, GAs have successfully been implemented in various application domains (Monteagudo and Santos 2015;Perez-Liebana et al 2015;Bak, Rask and Risi 2016;Davies et al 2016;Scirea et al 2016). However, a standard GA inherently and inevitably needs to evaluate all the solutions to obtain their objective-function values.…”
Section: S U R V E Y -P a R A M E T E R U P D A T Ementioning
confidence: 99%
“…Over several decades, the original definition of GAs has gradually evolved, and the technology has been widely adapted to a variety of optimization problems. Numerous successful applications of GAs are easily recognizable in different domains such as biomedicine (Monteagudo and Reyes 2015), arts (Davies et al 2016), architecture (Bak, Rask and Risi 2016), music (Scirea et al 2016), games (Liebana et al 2015) and recently machine learning (Kramer 2016).…”
Section: S U R V E Y D E S I G N W I T H G E N E T I C a L G O R I T mentioning
confidence: 99%