Evolutionary life history theory as an organising framework for cohort studies: insights from the Cebu Longitudinal Health and Nutrition Survey

Kuzawa, Christopher W.; Adair, Linda S.; Bechayda, Sonny Agustin; Borja, Judith Rafaelita; Carba, Delia; Duazo, Paulita; Eisenberg, Dan T. A.; Georgiev, Alexander V.; Gettler, Lee T.; Lee, Nanette R.; Quinn, Elizabeth A.; Rosenbaum, Stacy; Rutherford, Julienne N.; Ryan, Calen P.; McDade, Thomas W.

doi:10.1080/03014460.2020.1742787

Cited by 13 publications

(9 citation statements)

References 101 publications

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“…This approach is particularly promising for the domain of reproduction. A large body of work has documented the association between harshness and a short-term reproductive decision-making strategy (lower level of sexual commitment, lower level of parental investment) (Belsky et al, 2012;Kusawa et al, 2020). In harsher environment, individuals may thus feel more threatened by the sexual promiscuity of others and more willing to moralize them.…”

Section: Discussionmentioning

confidence: 99%

Predictive modeling of religiosity, prosociality, and moralizing in 295,000 individuals from European and non-European populations

Jacquet

Pazhoohi

Findling

et al. 2021

Humanit Soc Sci Commun

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Why do moral religions exist? An influential psychological explanation is that religious beliefs in supernatural punishment is cultural group adaptation enhancing prosocial attitudes and thereby large-scale cooperation. An alternative explanation is that religiosity is an individual strategy that results from high level of mistrust and the need for individuals to control others’ behaviors through moralizing. Existing evidence is mixed but most works are limited by sample size and generalizability issues. The present study overcomes these limitations by applying k-fold cross-validation on multivariate modeling of data from >295,000 individuals in 108 countries of the World Values Surveys and the European Value Study. First, this methodology reveals no evidence that European and non-European religious people invest more in collective actions and are more trustful of unrelated conspecifics. Instead, the individuals’ level of religiosity is found to be weakly but positively associated with social mistrust and negatively associated with the production of behaviors, which benefit unrelated members of the large-scale community. Second, our models show that individual variation in religiosity is well explained by the interaction of increased levels of social mistrust and increased needs to moralize other people’s sexual behaviors. Finally, stratified k-fold cross-validation demonstrates that the structures of these association patterns are robust to sampling variability and reliable enough to generalize to out-of-sample data.

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Section: Discussionmentioning

confidence: 99%

Predictive modeling of religiosity, prosociality, and moralizing in 295,000 individuals from European and non-European populations

Jacquet

Pazhoohi

Findling

et al. 2021

Humanit Soc Sci Commun

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“…Data come from the Cebu Longitudinal Health and Nutrition Survey, a longitudinal birth cohort study that started in 1983 in Metro Cebu, Philippines (Adair et al, 2011; Kuzawa et al, 2020). The mothers in this study, who represent the children in the original cohort, were contacted by phone to gauge their interest in participating in this phase of the study.…”

Section: Methodsmentioning

confidence: 99%

Prenatal household size and composition are associated with infant fecal bacterial diversity in Cebu, Philippines

Manus

Watson

Kuthyar

et al. 2023

American Journal of Biological Anthropology

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Objectives The gut microbiome (GM) connects physical and social environments to infant health. Since the infant GM affects immune system development, there is interest in understanding how infants acquire microbes from mothers and other household members. Materials and Methods As a part of the Cebu Longitudinal Health and Nutrition Survey (CLHNS), we paired fecal samples (proxy for the GM) collected from infants living in Metro Cebu, Philippines at 2 weeks (N = 39) and 6 months (N = 36) with maternal interviews about prenatal household composition. We hypothesized that relationships between prenatal household size and composition and infant GM bacterial diversity (as measured in fecal samples) would vary by infant age, as well as by household member age and sex. We also hypothesized that infant GM bacterial abundances would differ by prenatal household size and composition. Results Data from 16 S rRNA bacterial gene sequencing show that prenatal household size was the most precise estimator of infant GM bacterial diversity, and that the direction of the association between this variable and infant GM bacterial diversity changed between the two time points. The abundances of bacterial families in the infant GM varied by prenatal household variables. Conclusions Results highlight the contributions of various household sources to the bacterial diversity of the infant GM, and suggest that prenatal household size is a useful measure for estimating infant GM bacterial diversity in this cohort. Future research should measure the effect of specific sources of household bacterial exposures, including social interactions with caregivers, on the infant GM.

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“…To clarify the immunological processes associated with reproduction, we used the Illumina BeadChip 450k Array to examine genome-wide blood leukocyte DNA methylation (DNAm) in 394 women who were similar in age (20–21 years), but varied in reproductive status (nulliparous, pregnant, breastfeeding and parous) at the time of measurement. The women in this study are participants in the Cebu Longitudinal Health and Nutrition Survey, a long-term study of health and life histories in the Metropolitan Cebu Area, Philippines [ 38 , 39 ]. DNAm is a biochemical process that reflects chromatin accessibility and transcriptional activity, providing a tool for studying gene–environment interactions that often underlie development, aging and disease [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction

Ryan

Jones

Edgar

et al. 2022

Evolution, Medicine, and Public Health

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Background Consistent with evolutionarily-theorized costs of reproduction (CoR), reproductive history in women is associated with life expectancy and susceptibility to certain cancers, autoimmune disorders, and metabolic disease. Immunological changes originating during reproduction may help explain some of these relationships. Method ology: To explore the potential role of the immune system in female CoR, we characterized leukocyte composition and regulatory processes using DNA methylation (DNAm) in a cross-sectional cohort of young (20-22 year-old) women differing in reproductive status. Results Compared to nulliparity, pregnancy was characterized by differential methylation at 828 sites, 96% of which were hypomethylated and enriched for genes associated with T-cell activation, innate immunity, pre-eclampsia, and neoplasia. Breastfeeding was associated with differential methylation at 1107 sites (71% hypermethylated), enriched for genes involved in metabolism, immune self-recognition, and neurogenesis. There were no significant differences in DNAm between nulliparous and parous women. However, compared to nullipara, pregnant women had lower proportions of B, CD4T, CD8T, and natural killer (NK) cells, and higher proportions of granulocytes and monocytes. Monocyte counts were lower and NK counts higher among breastfeeding women, and remained so among parous women. Implications Our findings point to widespread differences in DNAm during pregnancy and lactation. These effects appear largely transient, but may accumulate with gravidity become detectable as women age. Nulliparous and parous women differed in leukocyte composition, consistent with more persistent effects of reproduction on cell type. These findings support transient (leukocyte DNAm) and persistent (cell composition) changes associated with reproduction in women, illuminating potential pathways contributing to CoR. LAY SUMMARY Evolutionary theory and epidemiology support costs of reproduction (CoR) to women’s health that may involve changes in immune function. We report differences in immune cell composition and gene regulation during pregnancy and breastfeeding. While many of these differences appear transient, immune cell composition may remain, suggesting mechanisms for female CoR.

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Evolutionary life history theory as an organising framework for cohort studies: insights from the Cebu Longitudinal Health and Nutrition Survey

Cited by 13 publications

References 101 publications

Predictive modeling of religiosity, prosociality, and moralizing in 295,000 individuals from European and non-European populations

Predictive modeling of religiosity, prosociality, and moralizing in 295,000 individuals from European and non-European populations

Prenatal household size and composition are associated with infant fecal bacterial diversity in Cebu, Philippines

Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction

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