2020
DOI: 10.1128/jvi.01127-19
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Abstract: The Amazon basin is home to numerous arthropod-borne viral pathogens that cause febrile disease in humans. Among these, Oropouche orthobunyavirus (OROV) is a relatively understudied member of the genus Orthobunyavirus, family Peribunyaviridae, that causes periodic outbreaks in human populations in Brazil and other South American countries. Although several studies have described the genetic diversity of the virus, the evolutionary processes that shape the OROV genome remain poorly understood. Here, we present … Show more

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Cited by 19 publications
(15 citation statements)
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References 83 publications
(99 reference statements)
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“…Important examples of these trends are the recent Zika virus epidemic, which had severe public health consequences in Central and South America [5][6][7][8], the yellow fever vaccination crisis in African countries [9] and (re)emergence of yellow fever virus in Brazil [9,10]. Other examples of mosquito-borne viruses experiencing recent surges include chikungunya, Mayaro, Usutu, Spondweni, Oropuche and West Nile viruses [1,3,11].…”
Section: Introductionmentioning
confidence: 99%
“…Important examples of these trends are the recent Zika virus epidemic, which had severe public health consequences in Central and South America [5][6][7][8], the yellow fever vaccination crisis in African countries [9] and (re)emergence of yellow fever virus in Brazil [9,10]. Other examples of mosquito-borne viruses experiencing recent surges include chikungunya, Mayaro, Usutu, Spondweni, Oropuche and West Nile viruses [1,3,11].…”
Section: Introductionmentioning
confidence: 99%
“…The group is most closely related to strain TVP-19256/IQE-7894 from Peru, 2008 (GenBank KP795084.1-KP795086.1). A comprehensive phylogenetic analysis of OROV in South America, including the Ecuadorian genomes, has been undertaken [26].…”
Section: Discussionmentioning
confidence: 99%
“…Primer and probe sequences were aligned using the ClustalW algorithm in the MEGA7 software package, to a set of OROV N gene coding sequences (GenBank) representing the geographic (Brazil, Panama, Peru and Trinidad and Tobago) and temporal diversity of OROV isolates from the 1950s to present day [26].…”
Section: Primer Alignmentmentioning
confidence: 99%
“…However, currently available data on OROV urban transmission do not support the possibility of a human-to-human cycle maintained by anthropophilic mosquitoes. Although urban epidemics caused over half a million human infections since first identified, OROV urban outbreaks were self-limited [ 16 , 30 , 31 , 32 , 33 ]. This suggests that OROV is able to start outbreaks in humans, mainly in regions on the fringes of forested areas, that evolve into self-limited outbreaks that eventually die out.…”
Section: Introductionmentioning
confidence: 99%