Evolutionary Dynamics of Accelerated Antiviral Resistance Development in Hypermutator Herpesvirus
Thomas Höfler,
Mariana Mara Nascimento,
Michaela Zeitlow
et al.
Abstract:Antiviral therapy is constantly challenged by the emergence of resistant pathogens. At the same time, experimental approaches to understand and predict resistance are limited by long periods required for evolutionary processes. Here, we present a herpes simplex virus 1 mutant with impaired proofreading capacity and consequently elevated mutation rates. Comparing this hypermutator to parental wild type virus, we study the evolution of antiviral drug resistance in vitro. We model resistance development and eluci… Show more
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