Evolutionary Divergence of Brain-specific Precursor miRNAs Drives Efficient Processing and Production of Mature miRNAs in Human

Chakraborty, Sajib; Islam, Rezaul; Ali, Muntasir; Nabi, A.H.M. Nurun

doi:10.1016/j.neuroscience.2018.09.010

Cited by 4 publications

(4 citation statements)

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“…While the molecular mechanisms of mRNA spatial distributions are well-studied, those of ncRNAs are still largely unknown. Emerging evidence indicates that miRNAs specifically localize within the brain, brain regions, and brain cells [31][32][33][34][35][36][37], but also in the subcellular compartments, including the axon [38][39][40][41][42][43][44][45]. Here, we briefly summarize the current knowledge of miRNA spatial distribution and associated transport mechanism within the axon.…”

Section: In the Right Place: Mirnas Are Translocated To Developing Axonsmentioning

confidence: 96%

“…Our survey of the available datasets yields interesting, if not always consistent clues. Subsets of miRNAs are specifically expressed in the brain (miR-103, -107, -124, -129, -134, -181, -191, -218) [34] or in brain and nervous system (NS)-related tissues (miR-9-5p, -124-3p, -219a-5p, -338-3p) [33], while seven unique miRNAs appear to be consistently detected in all axon types (miR-17-5p, miR-20a, miR-30b, miR-30c, miR-125a-5p, miR-125b-5p, miR-204) (Figure 1a). The relatively small size of the overlapping axonal miRNA pool is likely to stem from the wide differences in biological systems and detection techniques among the studies.…”

Section: Mirna and Pre-mirna Detection In Axonsmentioning

confidence: 99%

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In the Right Place at the Right Time: miRNAs as Key Regulators in Developing Axons

Corradi

Baudet

2020

IJMS

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During neuronal circuit formation, axons progressively develop into a presynaptic compartment aided by extracellular signals. Axons display a remarkably high degree of autonomy supported in part by a local translation machinery that permits the subcellular production of proteins required for their development. Here, we review the latest findings showing that microRNAs (miRNAs) are critical regulators of this machinery, orchestrating the spatiotemporal regulation of local translation in response to cues. We first survey the current efforts toward unraveling the axonal miRNA repertoire through miRNA profiling, and we reveal the presence of a putative axonal miRNA signature. We also provide an overview of the molecular underpinnings of miRNA action. Our review of the available experimental evidence delineates two broad paradigms: cue-induced relief of miRNA-mediated inhibition, leading to bursts of protein translation, and cue-induced miRNA activation, which results in reduced protein production. Overall, this review highlights how a decade of intense investigation has led to a new appreciation of miRNAs as key elements of the local translation regulatory network controlling axon development.

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Section: In the Right Place: Mirnas Are Translocated To Developing Axonsmentioning

confidence: 96%

Section: Mirna and Pre-mirna Detection In Axonsmentioning

confidence: 99%

In the Right Place at the Right Time: miRNAs as Key Regulators in Developing Axons

Corradi

Baudet

2020

IJMS

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“…A series of observations support the notion that miRNAs are instrumental contributors to the alterations that may account for the accelerated evolution of the human brain. First, elevated production of mature miRNAs has been observed in the human brain compared to other species, which is attributed to the higher processing efficiency of miRNA precursors in humans (Chakraborty et al, 2018). It has been proposed that the evolution of miRNA-mediated regulatory networks has contributed to organismal complexity (Berezikov, 2011).…”

Section: Mirnas As Key Regulators In Shaping Patterns Of Gene Expressmentioning

confidence: 99%

Species-Specific miRNAs in Human Brain Development and Disease

Prodromidou

Matsas

2019

Front. Cell. Neurosci.

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Identification of the unique features of human brain development and function can be critical towards the elucidation of intricate processes such as higher cognitive functions and human-specific pathologies like neuropsychiatric and behavioral disorders. The developing primate and human central nervous system (CNS) are distinguished by expanded progenitor zones and a protracted time course of neurogenesis, leading to the expansion in brain size, prominent gyral anatomy, distinctive synaptic properties, and complex neural circuits. Comparative genomic studies have revealed that adaptations of brain capacities may be partly explained by human-specific genetic changes that impact the function of proteins associated with neocortical expansion, synaptic function, and language development. However, the formation of complex gene networks may be most relevant for brain evolution. Indeed, recent studies identified distinct human-specific gene expression patterns across developmental time occurring in brain regions linked to cognition. Interestingly, such modules show speciesspecific divergence and are enriched in genes associated with neuronal development and synapse formation whilst also being implicated in neuropsychiatric diseases. microRNAs represent a powerful component of gene-regulatory networks by promoting spatiotemporal post-transcriptional control of gene expression in the human and primate brain. It has also been suggested that the divergence in miRNA expression plays an important role in shaping gene expression divergence among species. Primatespecific and human-specific miRNAs are principally involved in progenitor proliferation and neurogenic processes but also associate with human cognition, and neurological disorders. Human embryonic or induced pluripotent stem cells and brain organoids, permitting experimental access to neural cells and differentiation stages that are otherwise difficult or impossible to reach in humans, are an essential means for studying species-specific brain miRNAs. Single-cell sequencing approaches can further decode refined miRNA-mRNA interactions during developmental transitions. Elucidating species-specific miRNA regulation will shed new light into the mechanisms that control spatiotemporal events during human brain development and disease, an important step towards fostering novel, holistic and effective therapeutic approaches for neural disorders. In this review, we discuss species-specific regulation of miRNA function, its contribution to the evolving features of the human brain and in neurological disease, with respect also to future therapeutic approaches.

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“…miRNAs play crucial roles in almost all fundamental biological and metabolic processes [ 24 ]. Of all the mammalian miRNAs identified to date, more than 50% of them are expressed in the brain [ 25 , 26 ]. Recent studies have addressed miRNAs to be involved in various central nervous system’s pathologies [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Long-term potentiation and depression regulatory microRNAs were highlighted in Bisphenol A induced learning and memory impairment by microRNA sequencing and bioinformatics analysis

Luo

Ding

et al. 2023

PLoS ONE

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The mechanisms of Bisphenol A (BPA) induced learning and memory impairment have still not been fully elucidated. MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules involved in the process of toxicant-induced neurotoxicity. To investigate the role of miRNAs in BPA-induced learning and memory impairment, we analyzed the impacts of BPA on miRNA expression profile by high-throughput sequencing in mice hippocampus. Results showed that mice treated with BPA displayed impairments of spatial learning and memory and changes in the expression of miRNAs in the hippocampus. Seventeen miRNAs were significantly differentially expressed after BPA exposure, of these, 13 and 4 miRNAs were up- and downregulated, respectively. Bioinformatic analysis of Gene Ontology (GO) and pathway suggests that BPA exposure significantly triggered transcriptional changes of miRNAs associated with learning and memory; the top five affected pathways involved in impairment of learning and memory are: 1) Long-term depression (LTD); 2) Thyroid hormone synthesis; 3) GnRH signaling pathway; 4) Long-term potentiation (LTP); 5) Serotonergic synapse. Eight BPA-responsive differentially expressed miRNAs regulating LTP and LTD were further screened to validate the miRNA sequencing data using Real-Time PCR. The deregulation expression levels of proteins of five target genes (CaMKII, MEK1/2, IP3R, AMPAR1 and PLCβ4) were investigated via western blot, for further verifying the results of gene target analysis. Our results showed that LTP and LTD related miRNAs and their targets could contribute to BPA-induced impairment of learning and memory. This study provides valuable information for novel miRNA biomarkers to detect changes in impairment of learning and memory induced by BPA exposure.

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Evolutionary Divergence of Brain-specific Precursor miRNAs Drives Efficient Processing and Production of Mature miRNAs in Human

Cited by 4 publications

References 50 publications

In the Right Place at the Right Time: miRNAs as Key Regulators in Developing Axons

In the Right Place at the Right Time: miRNAs as Key Regulators in Developing Axons

Species-Specific miRNAs in Human Brain Development and Disease

Long-term potentiation and depression regulatory microRNAs were highlighted in Bisphenol A induced learning and memory impairment by microRNA sequencing and bioinformatics analysis

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