Evolutionary conservation of the linkage between the structural loci for serum albumin and vitamin D binding protein (Gc) in cattle

Abstract

Evidence is presented for close genetic linkage between the structural loci for serum albumin and the vitamin D binding protein (Gc) in Belgian Blue and White cattle. Five recombinants were observed in a total of 342 informative offspring. The recombination frequency between the two loci was estimated as 1.5% k 0.9. The observed distribution of the haplotypes deviated from the expected one in the population, probably due to selection and significant linkage disequilibrium.

Linkage between the loci for serum albumin and vitamin D binding protein (GC) in sheep

“…The estimated recombination rate between the ALB and GC loci in sheep is in agreement with the low recombination frequency between the two loci in species already studied (Weitkamp et al 1966;Sandberg & Juneja 1978;Juneja et al 1982;Bouquet et al 1986). Our results establish that the sheep linkage group (LGII) demonstrated by Levbziel et al (1991) which was recently mapped in addition with further markers as CASASl -CASASZ-PGMZ-ALB to chromosome 6 by somatic cell hybrids (Broad et al 1992) now comprises also the locus for GC.…”

“…Genetic linkage between the loci encoding serum albumin ( A D ) and vitamin D binding protein (GC) was first reported in man (Weitkamp et al 1966) and later in horse (Sandberg & Juneja 19781, chicken (Juneja et al 1982) and cattle (Bouquet et al 1986).…”

Polymorphic plasma postalbumin (Po) of llamas and alpacas identified as Gc protein

“…The Gc variation in llamas and alpacas identified here is important for comparative gene mapping in these species. Close linkage between Gc and albumin loci has previously been reported in various mammalian species and in chicken (see Bouquet et al 1986 and references therein). Inasmuch as albumin was found to be monomorphic in our previous study (Penedo er af.…”

Vitamin D Metabolism and Profiling in Veterinary Species

“…Very limited studies (especially in recent times) have examined species-based differences in VDBP levels, or primary protein sequences of the VDBP (as they relate to affinity of vitamin D metabolites) between species [234][235][236][237][238][239][240]. Circulating vitamin D metabolite concentrations are dependent on affinity to the VDBP, as well as metabolism and dietary intake [241][242][243].…”