Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy
Jae Seung Lee,
Mark Dittmar,
Jesse Miller
et al.
Abstract:SARS-CoV-2 emerged, and is evolving to efficiently infect humans worldwide. SARS-CoV-2 evades early innate recognition, interferon signaling activated only in bystander cells. This balance of innate activation and viral evasion has important consequences, but the pathways involved are incompletely understood. Here we find that autophagy genes regulate innate immune signaling, impacting the basal set point of interferons, and thus permissivity to infection. Mechanistically, autophagy genes negatively regulate M… Show more
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