Evolutionary and phylogeographic views on &lt;i&gt;Mc1r&lt;/i&gt; and &lt;i&gt;Asip&lt;/i&gt; variation in mammals

Suzuki, Hitoshi

doi:10.1266/ggs.88.155

Cited by 39 publications

(37 citation statements)

References 69 publications

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“…From the molecular perspective, pigmentation variation within and among species is widely observed and some causal genetic changes have been identified in many organisms (e.g. Miyagi and Terai, 2013;Suzuki, 2013). Moreover, the pigmentation biosynthesis pathway is one of the well-studied metabolic pathways in animals (reviewed in Sugumaran, 2002), and its key players have been known for a long time in insects (Wright, 1987).…”

Section: Introductionmentioning

confidence: 99%

Pigmentation and behavior: potential association through pleiotropic genes in <i>Drosophila</i>

Takahashi

2013

Genes Genet. Syst.

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The molecular basis of pigmentation variation within and among Drosophila species is largely attributed to genes in melanin biosynthesis pathway, which involves dopamine metabolism. Most of the genetic changes underlying pigmentation variations reported to date are changes at the expression levels of the structural genes in the pathway. Within D. melanogaster, changes in cis-regulatory regions of a gene, ebony, are responsible for the naturally occurring variation of the body pigmentation intensity. This gene is also known to be expressed in glia, and many visual and behavioral abnormalities of its mutants have been reported. This implies that the gene has pleiotropic functions in the nervous systems. In this review, current knowledge on pigmentation variation and melanin biosynthesis pathway are summarized, with some focus on pleiotropic features of ebony and other genes in the pathway. A potential association between pigmentation and behavior through such pleiotropic genes is discussed in light of cis-regulatory structure and pleiotropic mutations.

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Section: Introductionmentioning

confidence: 99%

Pigmentation and behavior: potential association through pleiotropic genes in <i>Drosophila</i>

Takahashi

2013

Genes Genet. Syst.

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“…However detailed roles of these candidate genes in cichlid pigmentation are largely unknown. Various types of pigmentation variations are observed in many animal species and the genetic factors generating such variations are identified in several organisms such as flies (Takahashi, 2013) and mammals (Suzuki, 2013). The information of the genes responsible for pigmentation variations in other animals may provide new insights into molecular mechanisms of the formation of male nuptial coloration in cichlids.…”

Section: Cichlid Colormentioning

confidence: 99%

The diversity of male nuptial coloration leads to species diversity in Lake Victoria cichlids

Miyagi

Terai

2013

Genes Genet. Syst.

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The amazing coloration shown by diverse cichlid fish not only fascinates aquarium keepers, but also receives great attention from biologists interested in speciation because of its recently-revealed role in their adaptive radiation in an African lake. We review the important role of coloration in the speciation and adaptive evolution of Lake Victoria cichlids, which have experienced adaptive radiation during a very short evolutionary period. Mature male cichlids display their colors during mate choice. The color of their skin reflects light, and the reflected light forms a color signal that is received by the visual system of females. The adaptive divergence of visual perceptions shapes and diverges colorations, to match the adapted visual perceptions. The divergence of visual perception and coloration indicates that the divergence of color signals causes reproductive isolation between species, and this process leads to speciation. Differences in color signals among coexisting species act to maintain reproductive isolation by preventing hybridization. Thus, the diversity of coloration has caused speciation and has maintained species diversity in Lake Victoria cichlids.

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“…Therefore, we considered that Tibetan sheep could be an interesting model for identifying coat-color candidate genes. Although there are over 300 genes identified with known roles in mammalian pigmentation, a few key genes have been identified as major regulators of pigment production in domestic animals (Rieder et al, 2001;Liu et al, 2009;Suzuki, 2013).…”

Section: Introductionmentioning

confidence: 99%

Analysis of agouti signaling protein (ASIP) gene polymorphisms and association with coat color in Tibetan sheep (Ovis aries)

et al. 2015

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ABSTRACT. Tibetan sheep, an indigenous breed, have a wide variety of phenotypes and a colorful coat, which make this breed an interesting model for evaluating the effects of coat-color gene mutations on this phenotypic trait. The agouti signaling protein (ASIP) gene is a positional candidate gene, as was inferred based on previous study. In our research, ASIP gene copy numbers in genomic DNA were detected using a novel approach, and the exon 2 g.100-104 mutation and copy number variation (CNV) of ASIP were associated with coat color in 256 sheep collected from eight populations with different coat colors by highresolution melting curve assay. We found that the relative copy numbers of ASIP ranged from one to eight in Tibetan sheep. All of the g.100-104 genotypes in the populations were in Hardy-Weinberg equilibrium, and there was no relationship between the g.100-104 genotype and coat color (P > 0.05). The single ASIP CNV allele was found to be almost entirely associated with solid-black coat color; however, not all solidblack sheep displayed the putative single ASIP CNV genotype. From our Coat color in Tibetan sheep study, we speculate that the ASIP CNV is under great selective pressure and the single ASIP CNV allows selection for black coat color in Tibetan sheep, but this does not explain all black phenotypes in Tibetan sheep.

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Evolutionary and phylogeographic views on <i>Mc1r</i> and <i>Asip</i> variation in mammals

Cited by 39 publications

References 69 publications

Pigmentation and behavior: potential association through pleiotropic genes in <i>Drosophila</i>

Pigmentation and behavior: potential association through pleiotropic genes in <i>Drosophila</i>

The diversity of male nuptial coloration leads to species diversity in Lake Victoria cichlids

Analysis of agouti signaling protein (ASIP) gene polymorphisms and association with coat color in Tibetan sheep (Ovis aries)

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