Evolutionarily Conserved Roles For Blood-Brain Barrier Xenobiotic Transporters In Endogenous Steroid Partitioning And Behavior

Hindle, Samantha J.; Munji, Roeben N.; Dolghih, Elena; Gaskins, Garrett; Orng, Souvinh; Ishimoto, Hiroshi; Soung, Allison; DeSalvo, Michael K.; Kitamoto, Toshihiro; Keiser, Michael J.; Jacobson, Matthew P.; Daneman, Richard; Bainton, Roland J.

doi:10.1101/131698

Cited by 8 publications

(12 citation statements)

References 65 publications

(8 reference statements)

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“…Thereby, paracellular diffusion is prohibited and all hydrophilic molecules can only enter or leave the nervous system in a controlled manner (Bainton et al, ; DeSalvo, Mayer, Mayer, & Bainton, ; Mayer et al, ; Volkenhoff et al, ). The transcriptome of the subperineurial and the perineurial glial cells has been determined, which shows that these cells are equipped with a large range of evolutionarily well conserved transporters to ensure nutritional homeostasis as well as the export of xenobiotics (DeSalvo et al, ; Hindle et al, ; Limmer et al, ). The activity of efflux systems is in part regulated by a circadian clock (Zhang, Yue, Arnold, Artiushin, & Sehgal, ).…”

Section: Surface Gliamentioning

confidence: 99%

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Drosophila glia: Few cell types and many conserved functions

Yildirim

Petri

Kottmeier

et al. 2018

Glia

128

153

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Glial cells constitute without any dispute an essential element in providing an efficiently operating nervous system. Work in many labs over the last decades has demonstrated that neuronal function, from action potential generation to its propagation, from eliciting synaptic responses to the subsequent postsynaptic integration, is evolutionarily highly conserved. Likewise, the biology of glial cells appears conserved in its core elements and therefore, a deeper understanding of glial cells is expected to benefit from analyzing model organisms such as Drosophila melanogaster. Drosophila is particularly well suited for studying glial biology since in the fly nervous system only a limited number of glial cells exists, which can be individually identified based on position and a set of molecular markers. In combination with the well‐known genetic tool box an unprecedented level of analysis is feasible, that not only can help to identify novel molecules and principles governing glial cell function but also will help to better understand glial functions first identified in the mammalian nervous system. Here we review the current knowledge on Drosophila glia to spark interest in using this system to analyze complex glial traits in the future.

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Section: Surface Gliamentioning

confidence: 99%

“…Third, xenobiotic exporters found in the mammalian blood–brain barrier are also found at the Drosophila blood–brain barrier (Hindle et al, ; Mayer et al, ).…”

Section: Conservation Of Processesmentioning

confidence: 99%

Drosophila glia: Few cell types and many conserved functions

Yildirim

Petri

Kottmeier

et al. 2018

Glia

128

153

View full text Add to dashboard Cite

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“…While the neural tube is chordate‐specific, fluid bathes the CNS in animals that are not chordates; major invertebrate phyla such as arthropods (including insects) and molluscs share this characteristic . Non‐chordate invertebrates form a nerve cord, and may form a brain, but these are not tubular.…”

Section: Brain Ventricles and Csf: A Deeply Conserved Systemmentioning

confidence: 99%

“…Non‐chordate invertebrates form a nerve cord, and may form a brain, but these are not tubular. The nerve cord and brain are bathed in hemolymph, which, like CSF, could contribute to buoyancy, deliver nutrients, and remove waste from the CNS . However, hemolymph also shares important roles and features with blood, making it difficult to conclude clear homology with CSF …”

Section: Brain Ventricles and Csf: A Deeply Conserved Systemmentioning

confidence: 99%

Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube

2020

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The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid (CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube is a hallmark of the chordate CNS, and a closed neural tube is essential for normal development. Development and function of the ventricular system is examined, emphasizing three interdigitating components that form a functional system: ventricle walls, CSF fluid properties, and activity of CSF constituent factors. The cellular lining of the ventricle both can produce and is responsive to CSF. Fluid properties and conserved CSF components contribute to normal CNS development. Anomalies of the CSF/ventricular system serve as diagnostics and may cause CNS disorders, further highlighting their importance. This review focuses on the evolution and development of the brain ventricular system, associated function, and connected pathologies. It is geared as an introduction for scholars with little background in the field.

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“…The Blood-Brain Barrier as a Chemical Defense Another key function of the BBB is to regulate the flux of neurotransmitters/neuromodulators, hormones, and other molecules from the blood to the brain and vice versa. The brief summary that follows is based on studies of mammals such as rats, dogs, and humans, even though several BBB mechanisms are surprisingly conserved in both vertebrates and invertebrates (see DeSalvo et al 2014;Hindle and Bainton 2014;Hindle et al 2017;Saili et al 2017). For some molecules such as serotonin and steroid hormones, the flux is bidirectional; other molecules only flow from the blood to the brain (influx) as, for example, insulin and thyroid hormone.…”

Section: Securing the Brain: Possible Hostmentioning

confidence: 99%

Invisible Designers: Brain Evolution Through the Lens of Parasite Manipulation

Giudice¹

2019

The Quarterly Review of Biology

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keywords behavior, brain evolution, hormones, neurobiology, parasite-host interactions, parasite manipulation abstract The ability of parasites to manipulate host behavior to their advantage has been studied extensively, but the impact of parasite manipulation on the evolution of neural and endocrine mechanisms has remained virtually unexplored. If selection for countermeasures has shaped the evolution of nervous systems, many aspects of neural functioning are likely to remain poorly understood until parasites-the brain's invisible designers-are included in the picture. This article offers the first systematic discussion of brain evolution in light of parasite manipulation. After reviewing the strategies and mechanisms employed by parasites, the paper presents a taxonomy of host countermeasures with four main categories, namely: restrict access to the brain; increase the costs of manipulation; increase the complexity of signals; and increase robustness. For each category, possible examples of countermeasures are explored, and the likely evolutionary responses by parasites are considered. The article then discusses the metabolic, computational, and ecological constraints that limit the evolution of countermeasures. The final sections offer suggestions for future research and consider some implications for basic neuroscience and psychopharmacology. The paper aims to present a novel perspective on brain evolution, chart a provisional way forward, and stimulate research across the relevant disciplines.

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Evolutionarily Conserved Roles For Blood-Brain Barrier Xenobiotic Transporters In Endogenous Steroid Partitioning And Behavior

Abstract: We propose a general mechanism for common behavioral side effects of 63 prescription drugs: pharmacologically challenging BBB efflux transporters 64 disrupts brain levels of endogenous substrates, and implicates the BBB in 65 behavioral regulation.

Cited by 8 publications

References 65 publications

Drosophila glia: Few cell types and many conserved functions

Drosophila glia: Few cell types and many conserved functions

Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube

Invisible Designers: Brain Evolution Through the Lens of Parasite Manipulation

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