Evolutionarily conserved CLE peptide signaling in plant development, symbiosis, and parasitism

Miyawaki, Kaori; Tabata, Ryo; Sawa, Shinichiro

doi:10.1016/j.pbi.2013.08.008

Cited by 51 publications

(51 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these signaling molecules, recent genetic and biochemical studies have focused on the roles of small peptides (Djordjevic et al 2015;Endo et al 2014). The CLAVATA3 (CLV3)/ESR-related (CLE) family is one of the best characterized small peptide family in plants, and in most cases leucine-rich repeat (LRR) receptor-like kinases (RLKs) function as the receptors that transmit signals to the downstream pathway (Cock and McCormick 2001;Miyawaki et al 2013). In plant development, the currently available data indicate that a significant feature of the signal transduction events mediated by CLE-LRR-RLK modules are associated with controlling the balance between cell proliferation and differentiation Abstract Cell-to-cell communication, principally mediated by short-or long-range mobile signals, is involved in many plant developmental processes.…”

Section: Introductionmentioning

confidence: 99%

Expression of the CLE-RS3 gene suppresses root nodulation in Lotus japonicus

et al. 2016

View full text Add to dashboard Cite

Cell-to-cell communication, principally mediated by short- or long-range mobile signals, is involved in many plant developmental processes. In root nodule symbiosis, a mutual relationship between leguminous plants and nitrogen-fixing rhizobia, the mechanism for the autoregulation of nodulation (AON) plays a key role in preventing the production of an excess number of nodules. AON is based on long-distance cell-to-cell communication between roots and shoots. In Lotus japonicus, two CLAVATA3/ESR-related (CLE) peptides, encoded by CLE-ROOT SIGNAL 1 (CLE-RS1) and -RS2, act as putative root-derived signals that transmit signals inhibiting further nodule development through interaction with a shoot-acting receptor-like kinase HYPERNODULATION ABERRANT ROOT FORMATION 1 (HAR1). Here, an in silico search and subsequent expression analyses enabled us to identify two new L. japonicus CLE genes that are potentially involved in nodulation, designated as CLE-RS3 and LjCLE40. Time-course expression patterns showed that CLE-RS1/2/3 and LjCLE40 expression is induced during nodulation with different activation patterns. Furthermore, constitutive expression of CLE-RS3 significantly suppressed nodule formation in a HAR1-dependent manner. TOO MUCH LOVE, a root-acting regulator of AON, is also required for the CLE-RS3 action. These results suggest that CLE-RS3 is a new component of AON in L. japonicus that may act as a potential root-derived signal through interaction with HAR1. Because CLE-RS2, CLE-RS3 and LjCLE40 are located in tandem in the genome and their expression is induced not only by rhizobial infection but also by nitrate, these genes may have duplicated from a common gene.

show abstract

Section: Introductionmentioning

confidence: 99%

Expression of the CLE-RS3 gene suppresses root nodulation in Lotus japonicus

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Since the discovery of CLV3 (Clark et al, 1995;Ito et al, 2006;Kondo et al, 2006;Ohyama et al, 2009), (putative) CLE genes have been identified in dicots, monocots, mosses, and algae (Jun et al, 2008;Oelkers et al, 2008;Miwa et al, 2009;Zhang et al, 2014;Strabala et al, 2014), and they were shown to act on diverse developmental processes, including shoot and root meristem development, nodulation, embryo and endosperm development, regulation of root architecture in response to nutrients, and vascular development (Hobe et al, 2003;Fiers et al, 2005;Hirakawa et al, 2008;Stahl et al, 2009;Jun et al, 2010;Mortier et al, 2010;Lim et al, 2011;Reid et al, 2011;Fiume and Fletcher, 2012;Okamoto et al, 2013;Araya et al, 2014;Richards et al, 2015;T.-T. Xu et al, 2015). Strikingly, plant-parasitic cyst nematodes also secrete CLE-like effector proteins that are required for successful nematode infection (Wang et al, 2010Replogle et al, 2011;Miyawaki et al, 2013). 3D structure modeling demonstrated that CLV3, CLE1, CLE2, and CLE6 shared a similar arch-shaped molecular structure with conserved residues at the C terminus and middle region, suggesting that these regions could be involved in receptor selection and binding .…”

Section: Peptides With Specific Posttranslational Modificationsmentioning

confidence: 99%

The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions

et al. 2015

View full text Add to dashboard Cite

“…The importance of small secreted peptides in cell-to-cell communication has been recognized in animals for many years. However, in plants, interest in small secreted peptides has been overshadowed by that in lipophilic non-peptide hormones, such as auxin and cytokinin (Matsubayashi and Sakagami, 2006; Betsuyaku et al, 2011; Miyawaki et al, 2013). The first plant small secreted peptide to be reported, tomato systemin (TomSys), was discovered in wounded tomato leaves (Green and Ryan, 1972; Pearce et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Maturation processes and structures of small secreted peptides in plants

Tabata

Sawa

2014

Front. Plant Sci.

Self Cite

View full text Add to dashboard Cite

In the past decade, small secreted peptides have proven to be essential for various aspects of plant growth and development, including the maintenance of certain stem cell populations. Most small secreted peptides identified in plants to date are recognized by membrane-localized receptor kinases, the largest family of receptor proteins in the plant genome. This peptide-receptor interaction is essential for initiating intracellular signaling cascades. Small secreted peptides often undergo post-translational modifications and proteolytic processing to generate the mature peptides. Recent studies suggest that, in contrast to the situation in mammals, the proteolytic processing of plant peptides involves a number of complex steps. Furthermore, NMR-based structural analysis demonstrated that post-translational modifications induce the conformational changes needed for full activity. In this mini review, we summarize recent advances in our understanding of how small secreted peptides are modified and processed into biologically active peptides and describe the mature structures of small secreted peptides in plants.

show abstract

Evolutionarily conserved CLE peptide signaling in plant development, symbiosis, and parasitism

Cited by 51 publications

References 62 publications

Expression of the CLE-RS3 gene suppresses root nodulation in Lotus japonicus

Expression of the CLE-RS3 gene suppresses root nodulation in Lotus japonicus

The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions

Maturation processes and structures of small secreted peptides in plants

Contact Info

Product

Resources

About