Evolution towards simplicity in bacterial small heat shock protein system
Piotr Karaś,
Klaudia Kochanowicz,
Marcin Pitek
et al.
Abstract:Evolution can tinker with multi-protein machines and replace them with simpler single-protein systems performing equivalent functions in equally efficient manner. It is unclear how, on a molecular level, such simplification can arise. With ancestral reconstruction and biochemical analysis we have traced the evolution of bacterial small heat shock proteins (sHsp), which help to refold proteins from aggregates using either two proteins with different functions (IbpA and IbpB) or a secondarily single sHsp that pe… Show more
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