Evolution thermique de vinylphosphoranes

Chiral Hypervalent, Pentacoordinated Phosphoranes

“…The monocyclic vinyl phosphoranes 21 were prepared by the reaction of cyclic phosphite 20 with dimethyl acetylenedicarboxylate in the presence of the appropriate phenol (Scheme 10) [56]. The formation of monocyclic phosphorane 23 was observed in the reaction of ylide 22 with hexafluoroacetone (Scheme 11) [57].…”

“…A similar reaction of ylide 24 with hexafluoroacetone gave monocyclic phosphorene 25 (Scheme 12) [57]. The monocyclic vinyl phosphoranes 21 were prepared by the reaction of cyclic phosphite 20 with dimethyl acetylenedicarboxylate in the presence of the appropriate phenol (Scheme 10) [56]. The monocyclic vinyl phosphoranes 21 were prepared by the reaction of cyclic phosphite 20 with dimethyl acetylenedicarboxylate in the presence of the appropriate phenol (Scheme 10) [56].…”

The Synthesis of GV143253A: A Case Study for the Use of Analytical and Statistical Tools to Elucidate the Reaction Mechanism and to Optimize the Process

“…The peak m / z 801 can be associated with 11 , which would correspond to the phosphorus detected at −29 ppm in the NMR spectra, produced in a lower amount in toluene than in chloroform. 11 can lose ethylene, giving 12 (the m / z 773) and ethanol giving 13 (the m / z 727). 13 was isolated by column chromatography and fully characterized by 1 H/ 13 C/ 31 P NMR spectroscopy, confirming its structure and, indirectly, its parents.…”