Evolution sanguine et tissulaire des taux de quinidine après une injection veineuse

Comparison of Two Spectrofluorometric Procedures for Quinidine Determination in Biological Fluids

“…On the other hand, mean concentration values of 182.08 (SD = 3.53 and CZ = 439) and 182.92 (SD = 4.80 and CZ = 5.97)pg/ml were found in the unwashed and washed pentanol-benzene (1:l) extract, respectively, of the same urine sample. In this last extraction method, the concentration of fluorescent quinidine molecules (quinidine, hydroquinidine, and their metabolites) is not reduced by the alkaline6 Confidence interval of the mean a t the 0.05 level of significance.…”

“…Although benzene is the most specific extraction solvent for unchanged quinidine, Armand and Badinand (6) found that alkaline washings of benzene extracts of dog urine removed an additional amount of metabolites without reducing significantly the amount of quinidine.…”

Study with Positron Emission Tomography of the Osmotic Opening of the Dog Blood-Brain Barrier for Quinidine and Morphine

“…Positron emission tomography (PET) allows a non-invasive, in-vivo monitoring of the distribution of labelled compounds. We used this technique to evaluate the effects of osmotic opening of the BBB with mannitol (Rapoport et a1 1980) on the distribution in dog brain of ["Clquinidine and ["Clmorphine, drugs with limited passage through the BBB in normal circumstances (Armand et al 1969;Hartvig et al 1984; Agon et al 1988). The findings with PET for ["Clquinidine and [llC]morphine were compared with the extent of osmotic BBB-opening measured according to the Evans blue staining method (Rapoport et al 1972).…”

Bioavailability of Three Commercial Sustained-Release Tablets of Quinidine in Maintenance Therapy

“…The tubes were subsequently centrifuged, and the plasma was removed and frozen until assayed by the specific spectrofluorometric procedure5 of Armand and Badinand (5,7). Although the specificity of this method is limited, it was sufficiently sensitive, accurate, and precise for the measurement of concentrations as low as 0.1 p g h l (5).…”

“…Total quinidine-derived fluorescence also was monitored by the protein precipitation method of Brodie and Udenfriend (8). For each urine void, the volume was determined and an aliquot was frozen until just prior to drug analysis by the method of Armand and Badinand (5,7). Quinidine levels are reported in terms of quinidine base.…”