Evolution Processes in Populations of Plantain, Growing around the Radiation Sources: Changes in Plant Genotypes Resulting From Bystander Effects And Chromosomal Instability

Adaptation and Radiation-Induced Chromosomal Instability Studied by Statistical Modeling~!2009-12-10~!2010-02-20~!2010-03-30~!

“…The adaptive process has three components [19,21]: primary radiation injury, which depends on the intensity of radiation (I rad ); late injury, which depends on the intensity of intercellular "bystander" (I byst ) and intracellular regulatory (I reg ) mechanisms; and selection, which depends on repair systems and environment conditions (Fig. 2).…”

“…These components can be presented by different combinations of P and G laws where P statistics describe the statistics of independent events [19,21,24] and G statistics characterize statistics after selection [16-19, 21, 24]. The primary injury and late damage follow the Poisson or binomial law [35].…”

“…In practice, the observed P distribution can be the sum of P distributions on the numbers of primary and late damages. The first distribution dominates if radiation intensity exceeds the regulation mechanisms of the late process (I rad > I reg ) [21]; its sample mean is therefore low [19]. For example, a dose rate of 19.1 cGy/h (time between two hits per cell = 5 sec) induces hits in cells in the first 2 min with averaged number of hits per cell 33.…”

“…Quantitative characteristics of adaptive processes can be estimated by statistical modeling [19]. The statistical investigations of adaptive processes in natural plantain populations growing near radiation sources were described earlier [20,21]. Here, we present modeling of laboratory experiments on seeds of a pure pea line in which we studied the influence of aging and heat stress on the low-dose-rate irradiation effect.…”

Some Features of Generation and Analysis of Distributions of Individuals on the Number and Occurrence Frequency of Blood Lymphocytes' Cells with Chromosomal Abnormalities

“…Средние показатели, на которые ориентируются исследователи-экспериментаторы [5], не позволяют выявить комплекс механизмов, обеспечивающих реакцию организмов на стресс. Изучение распределений по числу и частоте появления клеток с аберрациями хромосом (АК) среди пролиферирующих (способных к делению) клеток (ПК) дает возможность сделать предположения о механизмах и закономерностях процессов появления клеток с нарушениями, как об одном из проявлений реакции организма на стресс [6][7][8][9][10][11]. В основе распределений по числу и частоте АК лежит закон появления АК среди ПК, в котором число n ПК является параметром.…”