Abstract:Voltage‐gated sodium channels play important roles in the nervous system by enabling propagation of action potentials along axons. It has been suggested that sodium channels evolved from calcium channels before the split of animals and choanoflagellates, as deduced from studies of sequence motifs important in the ion selectivity of sodium and calcium channels. The sodium channel α gene was subsequently duplicated in the two whole‐genome duplication events (2R) in early vertebrate evolution, resulting in four g… Show more
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