Evolution of Ventricular Myocyte Electrophysiology

Rosati, Barbara; Dong, Min; Cheng, Lan; Yan, Qinghong; Liou, Shian-Ren; Sanguinetti, Michael C.; Wang, Hongsheng; McKinnon, David

doi:10.1016/j.bpj.2008.12.3691

Cited by 6 publications

(25 citation statements)

References 49 publications

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“…As previously mentioned, the APD scales over a wide range of body weights (Noujaim et al, 2007; Rosati et al, 2008), but at the cellular level, substantial differences exist in the action potential waveform. In species smaller than guinea pigs, repolarization is heavily dependent on the transient outward potassium current ( I to ), and to some extent, the inward rectifier potassium current ( I K1 ).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, physiological properties, such as mean arterial pressure and cell size, remain relatively constant across mammalian species (West and Brown, 2005). However, cardiac electrophysiological properties, such as heart rate and ECG intervals (Noujaim et al, 2004), as well as APD (Noujaim et al, 2007; Rosati et al, 2008), scale with BM. The mechanisms that underlie electrophysiological scaling are thought to involve complex changes in the expression of different ion channels and transporters that play integral roles in the electrical excitation and recovery of the heart (Rosati et al, 2008; Rosati and McKinnon, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Evolutionary differences among species can occur either due to modifications of gene regulation (regulatory evolution) or due to changes in protein structure and function (structural evolution) (Rosati et al, 2008; Rosati and McKinnon, 2009). The structural and functional properties of the ion channels responsible for APD, action potential morphology, and duration of myocyte contraction remain relatively similar across species.…”

Section: Introductionmentioning

confidence: 99%

“…However, their gene regulation and expression varies drastically. It is thought that this variation in gene regulation is responsible for the molecular and cellular mechanisms of scaling (Rosati et al, 2008; Rosati and McKinnon, 2009). …”

Section: Introductionmentioning

confidence: 99%

“…In species smaller than guinea pigs, repolarization is heavily dependent on the transient outward potassium current ( I to ), and to some extent, the inward rectifier potassium current ( I K1 ). In guinea pigs and larger species, the slow delayed rectifier potassium current ( I Ks ), the rapid delayed rectifier potassium current ( I Kr ), and I K1 control repolarization (Rosati et al, 2008). The presence of the large and rapid I to in smaller animals prevents the formation of a plateau phase, and consequently the shape of the action potential is “triangular”, whereas larger animals do exhibit an action potential plateau as well as a “spike and dome” appearance.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Allometric scaling of electrical excitation and propagation in the mammalian heart

Bassil

Zarzoso

Noujaim

2017

Journal of Theoretical Biology

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Variations in body mass impose constraints on the structure and function of mammalian species, including those of the cardiovascular system. Numerous biological processes, including cardiovascular parameters, have been shown to scale with body mass (BM) according to the law of allometric scaling: Y=Y =a·BMb (Y, biological process; a, normalization constant; b, scaling exponent, which in many instances is a multiple of ¼). These parameters include heart and breathing rates, intervals and subintervals of the electrocardiogram (ECG), action potential duration (APD), metabolic rate, and temporal properties of ventricular fibrillation. For instance, the hierarchical branching networks of the vascular system, and of the specialized conduction system in the heart have been proposed to be important determinants of allometric scaling. A global and unifying molecular mechanism of allometric scaling has not been put forth, but changes in gene expression have been proposed to play an important role. Even though it is accepted that differences in body size have cardiovascular effects, the use of scaling in the clinical setting is limited. An increase in the clinical utilization of scaling is thought to lead to improved cardiovascular disease diagnosis and management in patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Allometric scaling of electrical excitation and propagation in the mammalian heart

Bassil

Zarzoso

Noujaim

2017

Journal of Theoretical Biology

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Effects of acute warming on cardiac and myotomal sarco(endo)plasmic reticulum ATPase (SERCA) of thermally acclimated brown trout (Salmo trutta)

Vornanen

2020

J Comp Physiol B

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At high temperatures, ventricular beating rate collapses and depresses cardiac output in fish. The role of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) in thermal tolerance of ventricular function was examined in brown trout (Salmo trutta) by measuring heart SERCA and comparing it to that of the dorsolateral myotomal muscle. Activity of SERCA was measured from crude homogenates of cold-acclimated (+ 3 °C, c.a.) and warm-acclimated (+ 13 °C, w.a.) brown trout as cyclopiazonic acid (20 µM) sensitive Ca2+-ATPase between + 3 and + 33 °C. Activity of the heart SERCA was significantly higher in c.a. than w.a. trout and increased strongly between + 3 and + 23 °C with linear Arrhenius plots but started to plateau between + 23 and + 33 °C in both acclimation groups. The rate of thermal inactivation of the heart SERCA at + 35 °C was similar in c.a. and w.a. fish. Activity of the muscle SERCA was less temperature dependent and more heat resistant than that of the heart SERCA and showed linear Arrhenius plots between + 3 and + 33 °C in both c.a. and w.a. fish. SERCA activity of the c.a. muscle was slightly higher than that of w.a. muscle. The rate of thermal inactivation at + 40 °C was similar for both c.a. and w.a. muscle SERCA at + 40 °C. Although the heart SERCA is more sensitive to high temperatures than the muscle SERCA, it is unlikely to be a limiting factor for heart rate, because its heat tolerance, unlike that of the ventricular beating rate, was not changed by temperature acclimation.

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Comparative Physiology, Growth, and Development

Buck

2015

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

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Evolution of Ventricular Myocyte Electrophysiology

Cited by 6 publications

References 49 publications

Allometric scaling of electrical excitation and propagation in the mammalian heart

Allometric scaling of electrical excitation and propagation in the mammalian heart

Effects of acute warming on cardiac and myotomal sarco(endo)plasmic reticulum ATPase (SERCA) of thermally acclimated brown trout (Salmo trutta)

Comparative Physiology, Growth, and Development

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