Evolution of tidal volume requirements during the neonatal period in preterm infants supported by pressure limited ventilation

Greenough, Anne; Ali, Kamal; Mughal, Sabina; Cockar, Iram

doi:10.1183/1393003.congress-2017.pa2067

Cited by 2 publications

(1 citation statement)

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“…In a similar observational study of 18 infants with median GA of 25 weeks' who were ventilated for the first 28 days of age, despite carbon dioxide levels increasing significantly (from a mean PCO2 42 mmHg to 60 mmHg), mean exhaled tidal volumes steadily rose from 5.4 to 7.2 ml/kg. There was a corresponding increase in mean minute ventilation (263-368 ml/ kg/min) and a modest increase in peak inspiratory pressures (18.1-22.4 cm H 2 O) (43). The authors speculated that to maintain relative normocapnia, the increase in minute ventilation and tidal volume were required to compensate for an expansion of the anatomical dead space (via both distension of the upper airways as well as alveolar airspace dilation).…”

Section: Invasive Mechanical Ventilationmentioning

confidence: 99%

Respiratory support strategies in the prevention and treatment of bronchopulmonary dysplasia

Hysinger

Ahlfeld²

2023

Front. Pediatr.

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Neonates who are born preterm frequently have inadequate lung development to support independent breathing and will need respiratory support. The underdeveloped lung is also particularly susceptible to lung injury, especially during the first weeks of life. Consequently, respiratory support strategies in the early stages of premature lung disease focus on minimizing alveolar damage. As infants grow and lung disease progresses, it becomes necessary to shift respiratory support to a strategy targeting the often severe pulmonary heterogeneity and obstructive respiratory physiology. With appropriate management, time, and growth, even those children with the most extreme prematurity and severe lung disease can be expected to wean from respiratory support.

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Section: Invasive Mechanical Ventilationmentioning

confidence: 99%