Evolution of therapy for locally advanced rectal cancer

Altomare, Nicole J.; Mulcahy, Mary F.

doi:10.1002/jso.27531

Cited by 1 publication

(1 citation statement)

References 44 publications

(142 reference statements)

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“…Surgery as total mesorectal excision (TME) is the cornerstone of treatment in patients with rectal cancer; the algorithm of treatment in these patients varies in accordance to the disease stage, patient clinical status, and patient's preference, but most cases of earlystage rectal cancer (defined as T1-2 and node negativity) are managed by upfront surgery, while, in the case of local advanced rectal cancer (defined as T3-4 and/or nodal positivity), neoadjuvant chemoradiotherapy (CRT) before surgery is recommended [7].…”

Section: Introductionmentioning

confidence: 99%

Early Rectal Cancer and Local Excision: A Narrative Review

Binda,

Secco,

Tuccillo

et al. 2024

JCM

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A rise in the incidence of early rectal cancer consequent to bowel-screening programs around the world and an increase in the incidence in young adults has led to a growing interest in organ-sparing treatment options. The rectum, being the most distal portion of the large intestine, is a fertile ground for local excision techniques performed with endoscopic or surgical techniques. Moreover, the advancement in endoscopic optical evaluation and the better definition of imaging techniques allow for a more precise local staging of early rectal cancer. Although the local treatment of early rectal cancer seems promising, in clinical practice, a significant number of patients who could benefit from local excision techniques undergo total mesorectal excision (TME) as the first approach. All relevant prospective clinical trials were identified through a computer-assisted search of the PubMed, EMBASE, and Medline databases until January 2024. This review is dedicated to endoscopic and surgical local excision in the treatment of early rectal cancer and highlights its possible role in current and future clinical practice, taking into account surgical completion techniques and chemoradiotherapy.

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Section: Introductionmentioning

confidence: 99%