Evolution of the phenomenon of drug-resistance III. The origin of the development of resistance to sulphathiazole in
Escherichia coli
and
Staphylococcus aureus
Abstract:This study deals with the hourly determination of metabolic differences during growth with sulphathiazole (ST) between the ST-sensitive and ST-resistant strains of
Escherichia coli
and
Staphylococcus aureus
for the timing of the onset of resistance mechanism. The amounts of the extracellularly accumulated p-aminobenzoic acid (PAB), folic acid (FA) and citrovorum factor (CF) in the culture fluids and the growth rates are determined. As described in the preceding p… Show more
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