Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model

Yang, Hongtao; Wang, Cong; Liu, Chaoqiang; Chen, Houwen; Wu, Yifan; Han, Jintao; Jia, Z C; Lin, Woei; Zhang, Deyuan; Li, Wenting; Yuan, Wei; Guo, Hui; Li, Huafang; Yang, Guangxin; Kong, Deling; Zhu, Donghui; Takashima, Kazuki; Ruan, Liqun; Nie, Jian–Feng; Li, Xuan; Zheng, Yufeng

doi:10.1016/j.biomaterials.2017.08.022

Cited by 273 publications

(218 citation statements)

References 70 publications

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“…They observed that by increasing immersion time the corrosion rate of Zn developed faster than Fe and Mg, which is justified by the occurrence of localized corrosion in the surface of Zn samples. Similar behavior was reported in vivo [57]. The localized corrosion causes to lose the strength uniformity of an implant which makes its failure behavior more ambiguous.…”

Section: Disadvantages Of Zn and Its Alloyssupporting

confidence: 72%

“…It is considered to be one of the vital mineral elements participating in a variety of fundamental biological functions, including signal transduction, apoptosis regulation as well as nucleic acid metabolism, DNA and RNA polymerase, and organic ligands interactions [56][57][58]. Approximately 85% of the Zn content of body exists in bone and muscle [14] which serves a crucial role in the improvement of cell proliferation and osteo-related gene expressions of osteoblasts affecting bone in growth [59,60].…”

Section: Advantages Of Zn and Its Alloysmentioning

confidence: 99%

“…Therefore, the moderate degradation rate of Zn is faster than Fe but slower than Mg, which could be an ideal option for clinical applications, especially in terms of mechanical stability [55]. More recently, Yang et al [57] implanted pure Zn stents into the abdominal aorta of rabbits for 12 months. They reported that the stent was capable to serve mechanical stability for the first 6 months and degraded 41.75 ± 29.72% of the stent volume after 12 months of implantation without any severe inflammations, platelet aggregation, and thrombosis formation.…”

Section: Advantages Of Zn and Its Alloysmentioning

confidence: 99%

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Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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Section: Disadvantages Of Zn and Its Alloyssupporting

confidence: 72%

Section: Advantages Of Zn and Its Alloysmentioning

confidence: 99%

Section: Advantages Of Zn and Its Alloysmentioning

confidence: 99%

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Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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“…Intriguingly, observations of low cellular density and a distinct lack of smooth muscle cells adjacent to the implant interface indicates that the Zn 2+ ions released from a zinc implant may suppress restenosis pathways [80]. Yang et al [81] investigated the degradation of pure zinc stents over one year in a rabbit abdominal aorta model. They reported an excellent biocompatibility, without severe inflammation, platelet aggregation, thrombosis formation or obvious intimal hyperplasia.…”

Section: In Vivo Examinationmentioning

confidence: 99%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

227

124

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Abstract:In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn 2+ , is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn 2+ released from an implant may suppress harmful smooth muscle cells and restenosis in arteries, while stimulating beneficial osteogenesis in bone. An important limitation of pure zinc as a potential biodegradable structural support, however, lies in its low strength (σ UTS~3 0 MPa) and plasticity (ε < 0.25%) that are insufficient for most medical device applications. Developing high strength and ductility zinc with sufficient hardness, while retaining its biocompatibility, is one of the main goals of metallurgical engineering. This paper will review and compare the biocompatibility, corrosion behavior and mechanical properties of pure zinc, as well as currently researched zinc alloys.

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“…The other reactions (3) and (4) are likely to occur on the surface of the Zn implant. Again, note that this occurs without releasing any hydrogen gas, which is unlike Mg implants, where controlling hydrogen gas release is an important consideration [3,8,9]. Due to the presence of chloride ions in normal physiological solutions, Zn(OH) 2 and ZnO would aggressively react with chloride ions forming more soluble chloride salts such as Zn(OH) 2 .ZnCl 2 .…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Testing of Zinc as a Biodegradable Material for Stents Fabricated by Photo-Chemical Etching

et al. 2019

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There is an increasing interest in biodegradable metal implants made from magnesium (Mg), iron (Fe), zinc (Zn) and their alloys because they are well tolerated in vivo and have mechanical properties that approach those of non-degradable metals. In particular, Zn and its alloys show the potential to be the next generation of biodegradable materials for medical implants. However, Zn has not been as well-studied as Mg, especially for stent applications. Manufacturing stents by laser cutting has become an industry standard. Nevertheless, the use of this approach with Zn faces some challenges, such as generating thermal stress, dross sticking on the device, surface oxidation, and the need for expensive thin-walled Zn tubing and post-treatment. All of these challenges motivated us to employ photo-chemical etching for fabricating different designs of Zn (99.95% pure) stents. The stents were constructed with different strut patterns, made by photo-chemical etching, and mechanically tested to evaluate radial forces. Stents with rhombus design patterns showed a promising 0.167N/mm radial force, which was comparable to Mg-based stents. In vitro studies were conducted with uncoated Zn stents as control and Parylene C-coated Zn stents to determine corrosion rates. The Parylene C coating reduced the corrosion rate by 50% compared to uncoated stents. In vivo studies were carried out by implanting photo-chemically etched, uncoated Zn stent segments subcutaneously in a C57BL/6 mice model. Histological analyses provided favorable data about the surrounding tissue status, as well as nerve and blood vessel responses near the implant, providing insights into the in vivo degradation of the metal struts. All of these experiments confirmed that Zn has the potential for use in biodegradable stent applications.

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Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model

Cited by 273 publications

References 70 publications

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

In Vitro and In Vivo Testing of Zinc as a Biodegradable Material for Stents Fabricated by Photo-Chemical Etching

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