Evolution of the acute phase response: iron release by echinoderm (Asterias forbesi) coelomocytes, and cloning of an echinoderm ferritin molecule

Beck, Gregory; Ellis, Thomas W.; Habicht, Gail S.; Schluter, Samuel F.; Marchalonis, John J.

doi:10.1016/s0145-305x(01)00051-9

Cited by 117 publications

(68 citation statements)

References 55 publications

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“…Upregulation of ferritin and selenium-binding-protein by infected host cells can trigger iron and selenium sequestration, thereby reducing the amount of these essential trace elements necessary for bacterial growth. Infection-induced iron and selenium sequestration by ferritin and selenium-binding-protein have been observed in several other invertebrate-bacteria interactions (Beck et al, 2002;Song et al, 2006;Altincicek et al, 2008;Li et al, 2008;Kong et al, 2010;Simão et al, 2010), and the crucial role of ferritin in antibacterial defense was recently demonstrated in a study showing that the injection of recombinant ferritin into Vibrio harveyi-infected shrimp (Peneaus monodon) increased the host survival rate (Maiti et al, 2010).…”

Section: Discussionmentioning

confidence: 93%

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Vidal-Dupiol

Ladrière

Meistertzheim

et al. 2011

Journal of Experimental Biology

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SUMMARYAs the effects of climate change have become increasingly visible over the past three decades, coral reefs have suffered from a number of natural and anthropogenic disturbances that have caused a critical decline in coral populations. Among these disturbances are coral diseases, which have appeared with increasing frequency and severity, often in correlation with increases in water temperature. Although the crucial role played by Vibrio species in coral disease has been widely documented, the scientific community does not yet fully understand the infection process of Vibrio or its impact on coral physiology and immunology. Here, we investigated the physiological and transcriptomic responses of a major reef-building coral, Pocillopora damicornis, when exposed to a specific pathogen (Vibrio coralliilyticus) under virulent (increasing water temperature) and nonvirulent (constant low temperature) conditions. The infection process was examined by electron microscopy and quantitative reverse-transcription PCR, and coral health was monitored by visual observations and measurements of zooxanthellar density. The results obtained suggest that coral tissue invasion occurs upon increasing water temperature only. Transcriptomic variations were investigated using a suppression-subtractive-hybridization approach, and the expression levels of six candidate immunerelated genes were examined during bacterial exposure. These genes correspond to three lectin-like molecules putatively involved in the recognition of pathogens, two metal-binding proteins putatively involved in antibacterial response and one cystein protease inhibitor. The transcription patterns of these selected genes provide new insights into the responses of coral colonies to virulent versus non-virulent bacteria. Supplementary material available online at

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Section: Discussionmentioning

confidence: 93%

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Vidal-Dupiol

Ladrière

Meistertzheim

et al. 2011

Journal of Experimental Biology

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“…Similarly, increased metal ion binding (specifically iron) was noted from challenged snails. The sequestering of iron in response to pathogens by vertebrates and invertebrates is considered an ancient host defense response (Beck et al, 2002;Weinberg and Weinberg, 1995). Finally, the consistency of differences in GO annotation between treatment and control group lends confidence to the validity of this method of transcriptome comparison.…”

Section: Discussionmentioning

confidence: 99%

Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails

Hanelt

Lun

Adema

2008

Journal of Invertebrate Pathology

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The snail Biomphalaria glabrata (Gastropoda, Mollusca) is an important intermediate host for the human parasite Schistosoma mansoni (Digenea, Trematoda). Anti-pathogen responses of B. glabrata were studied towards a better understanding of snail immunity and host-parasite compatibility. Open reading frame ESTs (ORESTES) were sampled from different transcriptomes of M line strain B. glabrata, 12 hours post challenge with Escherichia coli (Gram-negative), Micrococcus luteus (Gram-positive) bacteria or compatible S. mansoni, and controls. The resulting 3123 ORESTES represented 2129 unique sequences (373 clusters, 1756 singletons). Of these, 175 (8.1%) were putative defense factors, including lectins, antimicrobial peptides and components of various immune effector systems. Comparison of biological processes (GO-terms) within different transcriptomes indicated that B. glabrata increased oxygen transport and metal binding in reaction to all challenges. Comprehensive comparisons of transcriptomes revealed that responses of B. glabrata against bacteria were similar to each other and differed from the ineffective response to S. mansoni. Furthermore, the response to S. mansoni infection was less comprehensive than that to bacteria. Many novel (unknown) sequences were recovered in association with particular challenges. Biomphalaria glabrata possesses multi-faceted, potent immune defenses. This agrees with the notion that S. mansoni is capable of immune-evasion and prevents effective host defense responses in order to survive in B. glabrata. Future analysis of the numerous unknown sequences recovered from challenged snails may reveal novel immune factors and provide increased understanding of immunity of B. glabrata in relation to parasite-host compatibility.

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“…We observed that FTH1 was also up-regulated during R. anatipestifer infection compared with control individuals by quantitative RT-PCR. Ferritin up-regulation has also been described after immune challenge in starfish (Beck et al, 2002) and sea bass (Neves et al, 2009). In addition, the expression of the heavy chains of ferritin is under the control of the NF-kB signalling pathway in mammals.…”

Section: Discussionmentioning

confidence: 96%

Gene expression responses toRiemerella anatipestiferinfection in the liver of ducks

Zhou

Xiao

et al. 2013

Avian Pathology

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Riemerella anatipestifer is one of the most economically important pathogens of farm ducks worldwide. The molecular mechanisms that underlie its pathogenesis, particularly the host response to R. anatipestifer infection, are poorly understood. The differentially expressed gene profile of duck livers at 24 h following R. anatipestifer infection was therefore investigated using suppression subtractive hybridizaton analysis. A total of 45 differentially expressed genes were identified, which primarily included genes for proteins involved in acute-phase response, inflammatory response, immune response, wound healing and iron homeostasis. For the expression level of 20 genes from those 45 analysed by quantitative reverse transcriptase-polymerase chain reaction at 8, 24 and 48 h post infection, significant differences were observed among the three time points of measurements. The result from this study revealed a gene expression profile of duck liver during R. anatipestifer infection, and those genes with a role in the immune response and wound healing deserving further investigation to elucidate their respective roles during infection.

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Evolution of the acute phase response: iron release by echinoderm (Asterias forbesi) coelomocytes, and cloning of an echinoderm ferritin molecule

Cited by 117 publications

References 55 publications

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails

Gene expression responses toRiemerella anatipestiferinfection in the liver of ducks

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