Abstract:Background
Clostridium difficile-associated diarrhea (CDAD) is the commonest cause of nosocomial diarrhea.
Methods for C.difficle detection include toxins or enzyme detection by immunoassays, cytotoxicity neutralization assay (CCNA) or FDA approved PCR. Due to the tedious and time consuming nature of the CCNA and the suboptimal specificity and sensitivity of EIAs, these assays cannot be used as stand-alone tests. One approach of combining these assays, is by two-step algorithm, where Ag-EIAs is used as screeni… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.