Evolution of surveillance methods for detection of bacterial contamination of platelets in a university hospital, 1991 through 2004

Yomtovían, Roslyn; Palavecino, Elizabeth; Dysktra, Alden H.; Downes, Katharine A.; Morrissey, Anne M.; Bajaksouzian, Saralee; Pokorny, Marcella A.; Lazarus, Hillard M.; Jacobs, Michael

doi:10.1111/j.1537-2995.2006.00790.x

Cited by 85 publications

(131 citation statements)

References 39 publications

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“…10 Culture was repeated on platelet specimens with initial positive culture results from samples retained at 4°C to determine whether results were true or false positives. True positives were defined as isolation of the same bacterial species from the repeat culture.…”

Section: Microbiology Methodsmentioning

confidence: 99%

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Hong

Xiao

Lazarus

et al. 2016

Blood

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169

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• Bacterial sepsis from contaminated platelet transfusions continues to occur despite recent interventions; additional measures are needed.• STR to platelet transfusion is frequently not recognized or reported; use of recent AABB criteria showed highest diagnostic sensitivity.Septic transfusion reactions (STRs) resulting from transfusion of bacterially contaminated platelets are a major hazard of platelet transfusion despite recent interventions. Active and passive surveillance for bacterially contaminated platelets was performed over 7 years (2007)(2008)(2009)(2010)(2011)(2012)(2013) by culture of platelet aliquots at time of transfusion and review of reported transfusion reactions. All platelet units had been cultured 24 hours after collection and released as negative. Five sets of STR criteria were evaluated, including recent AABB criteria; sensitivity and specificity of these criteria, as well as detection by active and passive surveillance, were determined. Twenty of 51 440 platelet units transfused (0.004%; 389 per million) were bacterially contaminated by active surveillance and resulted in 5 STRs occurring 9 to 24 hours posttransfusion; none of these STRs had been reported by passive surveillance. STR occurred only in neutropenic patients transfused with high bacterial loads. A total of 284 transfusion reactions (0.55%) were reported by passive surveillance. None of these patients had received contaminated platelets. However, 6 to 93 (2.1%-32.7%) of these 284 reactions met 1 or more STR criteria, and sensitivity of STR criteria varied from 5.1% to 45.5%. These results document the continued occurrence of bacterial contamination of platelets resulting in STR in neutropenic patients, failure of passive surveillance to detect STR, and lack of specificity of STR criteria. These findings highlight the limitations of reported national STR data based on passive surveillance and the need to implement further measures to address this problem such as secondary testing or use of pathogen reduction technologies. (Blood. 2016;127(4):496-502)

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Section: Microbiology Methodsmentioning

confidence: 99%

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Hong

Xiao

Lazarus

et al. 2016

Blood

Self Cite

169

231

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“…Assuming that the average hematology oncology patient may receive seven platelet concentrates during a 28-day period of support, the risk of exposure to a contaminated platelet concentrate is in the range of one in 150 per patient (Corash, 2011): "This level of risk would not be acceptable for other intravenous medications." Several studies (Yomtovian 2004;Yomtovian et al, 2006Yomtovian et al, , 2007 identified the major sources of contamination as donor skin and asymptomatic bacteremia. Less frequently, contamination of PRP may occur during processing or manufacture of blood collection devices (Blajchman et al, 2005).…”

Section: Iccvam Recommendations For Future Mat Validation Studies Maymentioning

confidence: 99%

The human whole blood pyrogen test – lessons learned in twenty years

Hartung

2015

ALTEX

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“…Several studies on bacterial contamination of blood products have reported platelets as the most commonly contaminated blood product [3,5,6,[14][15][16]. In the United States, platelets accounted for the most common transfusion-associated infectious risk; they were reported to cause a 50-to 250-fold increase in the risk of transmission of HIV, HBV, and HCV [14].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of bacterial contamination in blood and blood products at the National Blood Service Zimbabwe

Makuni

Simango

Mavenyengwa

2015

J Infect Dev Ctries

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Introduction: Advances in screening for infections improve the safety of donated blood. Transfusion-related bacterial sepsis, although not established in Zimbabwe, stills makes bacterial contamination of blood clinically relevant. Methodology: This cross-sectional study was conducted in Harare. Bacteriological and antibiotic susceptibility testing were done using standard methods. Results: Of the 196 samples analyzed, 6 (3.1%) were contaminated with bacteria. Platelets had a significantly high contamination rate compared to other blood products. Bacteria showed varying patterns of susceptibility to the antibiotics tested. Conclusions: The prevalence of bacterial contamination in blood products suggests that patients who receive blood products are at risk of developing infection.

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Evolution of surveillance methods for detection of bacterial contamination of platelets in a university hospital, 1991 through 2004

Abstract: Improved active surveillance methods for detecting PBC are needed to improve the safety of PLT transfusions.

Cited by 85 publications

References 39 publications

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

The human whole blood pyrogen test – lessons learned in twenty years

Prevalence of bacterial contamination in blood and blood products at the National Blood Service Zimbabwe

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