Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis

Morel, Yves; Roucher, F; Plotton, Ingrid; Goursaud, Claire; Tardy, Véronique; Mallet, Delphine

doi:10.1016/j.ando.2016.04.023

Cited by 93 publications

(66 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is similar to the variation pattern of plasma steroid hormone in pregnant women that the level of P 4 and E 2 were significant increased through gestation week 12, 25 and 33 [10], and peak level was found in the third trimester [11,12]. And it also agrees with the tendency of saliva CORT level in gestation women, which was increased across the gestation period [13].…”

Section: Discussionsupporting

confidence: 76%

The Changes of Fecal Steroid Hormones and Bacterial Composition in Different Gestation Stages of Meishan Sows

Xue¹,

Jiang²,

Liu³

et al. 2017

J Nutr Food Sci

View full text Add to dashboard Cite

Currently, the importance of gut microbiota to the health of their host has been well discussed, yet the knowledge about the host hormonal effect on the gut microbiota is limited. In this study, a combination of the high-throughput 16S rRNA gene-based pyrosequencing and the Mass Spectrometry (MS)-based metabolomics techniques were used to investigate the stool microbial composition and microbial metabolites at different gestation day in Meishan sows. The results showed that, the stool steroid hormones including estradiol (E 2 ), progesterone (P 4 ) and cortisol (CORT) were increased at gestation day 90 (P<0.05), when compared to gestation day 30. In coincide with the changes of steroid hormones, the relative abundance of Burkholderiales and Selenomonadales of the stool microbiota at d90 of pregnancy was significantly increased than that of at d30 of pregnancy at the order level (P<0.05). However, no significant difference of the richness estimators (ACE and Chao), and the diversity indices (Shannon and Simpson) were found between the d30 and d90 of gestation. Further, the metabolomics profile revealed 13 metabolites changed greatly from the gestation day 30 to 90, including amino acid metabolic pathway, lipid and carbohydrate metabolic pathway (P<0.001). The results suggest that the interaction of the steroid hormones and the gut bacteria may account for the metabolic changes throughout the length of pregnancy.

show abstract

Section: Discussionsupporting

confidence: 76%

The Changes of Fecal Steroid Hormones and Bacterial Composition in Different Gestation Stages of Meishan Sows

Xue¹,

Jiang²,

Liu³

et al. 2017

J Nutr Food Sci

View full text Add to dashboard Cite

show abstract

“…Along with these elements, some studies have shown that progesterone also has a role in developmental oligodendrogenesis and the myelination process [19]; in fact, because the main role of this hormone lies in the maintenance of pregnancy, progesterone is constitutively present in the maternal and embryo-fetal circulation throughout development [20], and continues to be synthesized in the CNS of both females and males after birth [21]. In the adult, it regulates different functions such as neuroprotection, neurogenesis, neuronal plasticity, sexual behavior, mood, learning, and memory [22,23].…”

Section: Introductionmentioning

confidence: 99%

Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis

González-Orozco

Moral-Morales

2020

Cells

View full text Add to dashboard Cite

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). These cells arise during the embryonic development by the specification of the neural stem cells to oligodendroglial progenitor cells (OPC); newly formed OPC proliferate, migrate, differentiate, and mature to myelinating oligodendrocytes in the perinatal period. It is known that progesterone promotes the proliferation and differentiation of OPC in early postnatal life through the activation of the intracellular progesterone receptor (PR). Progesterone supports nerve myelination after spinal cord injury in adults. However, the role of progesterone in embryonic OPC differentiation as well as the specific PR isoform involved in progesterone actions in these cells is unknown. By using primary cultures obtained from the embryonic mouse spinal cord, we showed that embryonic OPC expresses both PR-A and PR-B isoforms. We found that progesterone increases the proliferation, differentiation, and myelination potential of embryonic OPC through its PR by upregulating the expression of oligodendroglial genes such as neuron/glia antigen 2 (NG2), sex determining region Y-box9 (SOX9), myelin basic protein (MBP), 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNP1), and NK6 homeobox 1 (NKX 6.1). These effects are likely mediated by PR-B, as they are blocked by the silencing of this isoform. The results suggest that progesterone contributes to the process of oligodendrogenesis during prenatal life through specific activation of PR-B.

show abstract

“…Via the enzyme aromatase, androstenedione can be converted to estrone, testosterone can be converted to estradiol 13 , and 16-OH-testosterone can be converted to estriol in the placental unit 14 . It is reported that the level of maternal testosterone increases 14 while the level of DHEAS decreases approximately two times during the course of pregnancy 15 . As a result hormonal differences regarding to fetal gender, its relation to sexual habits of pregnant women needs to be issued more.…”

Section: Introductionmentioning

confidence: 99%

Gebelerde cinsel fonksiyon değerlendirmesi: Serum androjen ve fetal cinsiyet ilişkisi

Astepe

2019

Zeynep Kamil Tıp Bülteni

View full text Add to dashboard Cite

Aim:As a result of physical and hormonal changes during pregnancy sexual health of women affected significantly. Material and Methods:To evaluate sexual changes related to androgenic hormones and fetal gender in pregnant Turkish women. Main Outcome Measures:This cross-sectional study included 194 healthy pregnant women evaluated at Obstetrics and Gynecology Clinics. Pregnant women completed a self-administered questionnaire including the Female Sexual Function Index (FSFI) and questions related to socio-demographic characteristics. Serum androgens were run simultaneously. Results:There was a rate of 68% sexual dysfunction among Turkish pregnant women. The sexual dysfunction rate comprises the total and domain scores of FSFI throughout the pregnancy. Although the total and domain scores of FSFI did not differ between trimesters, orgasm domain scores were found to be decreasing with increasing gestational age. Along with an increase in total testosterone, the DHEAS level decreases with increasing gestational age. When the women with female fetus were evaluated for FSFI scores and androgen levels between trimesters, the mean level of total testosterone in third trimester was higher than the levels of first and second trimesters besides the mean level of DHE-AS in the first trimester was higher than the levels of second and third trimesters. There was not any significant difference according to the androgen levels, FSFI total and domain scores between trimesters of the women with male fetus. Conclusion:We found a high sexual dysfunction rate (68%) among pregnant Turkish women. The level of total testosterone, DHEAS and FSFI orgasm domain were found to be different between trimesters. Healthcare providers should provide more time for counseling about sexuality and encourage pregnant women to talk about sexual health and problems during antenatal visits. ÖZETGiriş: Hamilelik sırasında fiziksel ve hormonal değişiklikler sonucunda kadınların cinsel sağlığı önemli derecede etkilenmektedir. Amaç: Hamile Türk kadınlarda cinsel değişiklikler ile androjenik hormonlar ve fetal cinsiyet ilişkisini değerlendirmek. Gereç ve Yöntemler: Bu kesitsel çalışma Kadın Hastalıkları ve Doğum Kliniği'nde değerlendirilen 194 sağlıklı gebeyi içermektedir. Gebe kadınlar, Kadın cinsel işlev ölçeği(KCİÖ) ve sosyodemografik özelliklerle ilgili sorular içeren ,kendi kendine uygulanan bir anket doldurdu. Serum androjenleri aynı zamanda çalışıldı. FSFI toplam ve altgrup puanları, maternal serum total testosteron , dehidroepiandrosteron sülfat(DHEAS) ve 1-4 delta androstenedion düzeyleri ölçüldü. Bulgular: Türk gebe kadınlarda %68 oranında cinsel işlev bozukluğu bulundu. Cinsel işlev bozukluğu oranı, gebelik boyunca KCİÖ'nin toplam ve altgrup puanlarını içerir. KCİÖ'nin toplam ve altgrup puanları trimesterlar arasında farklılık göstermese de , gebelik haftası ilerledikçe orgazm altgrup puanının azaldığı bulundu. Bunun yanında gebelik haftası ilerledikçe toplam testosteron artışıyla beraber DHEAS düzeyinin azaldığı görüldü. Kız fetüslü kadınlarda KC...

show abstract

Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis

Cited by 93 publications

References 61 publications

The Changes of Fecal Steroid Hormones and Bacterial Composition in Different Gestation Stages of Meishan Sows

The Changes of Fecal Steroid Hormones and Bacterial Composition in Different Gestation Stages of Meishan Sows

Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis

Gebelerde cinsel fonksiyon değerlendirmesi: Serum androjen ve fetal cinsiyet ilişkisi

Contact Info

Product

Resources

About