Evolution of Simplified Frozen Elephant Trunk Repair for Acute DeBakey Type I Dissection: Midterm Outcomes

Roselli, Eric E.; Idrees, Jay J.; Bakaeen, Faisal G.; Tong, Michael Z.; Soltesz, Edward G.; Mick, Stephanie; Johnston, Douglas R.; Eagleton, Mathew; Menon, Venu; Svensson, Lars G.

doi:10.1016/j.athoracsur.2017.08.037

Cited by 121 publications

(93 citation statements)

References 25 publications

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“…When we compared studies performed only in patients with acute type A aortic dissection (n ¼ 12, 1300 patients) 21,23,25,[27][28][29][30]35,37,41,46,47 with studies performed only in patients with nonacute type A dissection and aneurysm (n ¼ 14, 741 patients), 14,15,17,19,22,[24][25][26]34,40,[42][43][44][45] we found the following results: The pooled mortality rate was 9.2% (95% CI, 6.9-12.4) in the patients with acute type A and 7.6% (95% CI, 4.9-11.4) in the patients with nonacute dissection and aneurysm (P ¼ .46). The pooled rate of stroke in these 2 groups was 9.3% (95% CI, 4.5-18.5) and 6.6% (95% CI, 3.1-13.5) (P ¼ .51), and the pooled rate of SCI was 2.4% (95% CI, 1.3-4.2) and 5.2% (95% CI, 3.1-8.5) (P ¼ .05), respectively ( Figure E2).…”

Section: Acute Type a Versus Nonacute Type A And Aneurysmmentioning

confidence: 99%

Neurologic complications after the frozen elephant trunk procedure: A meta-analysis of more than 3000 patients

Preventza

Liao

Olive

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

165

135

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Objective: The frozen elephant trunk technique's safety regarding spinal cord ischemia has been questioned. We used a meta-analysis to determine the rates of adverse neurologic events and mortality. Methods:We searched PubMed/Medline, Embase, Scopus, and Cochrane databases (inception to April 2018) to identify studies of neurologic events after the frozen elephant trunk procedure. Separate meta-analyses were conducted with random-effects models to assess frozen elephant trunk associations with spinal cord ischemia, stroke, operative mortality, and all adverse events combined. Subgroup analyses compared outcomes in patients with acute versus nonacute type A dissection and aneurysm and with different extents of coverage.Results: Thirty-five studies (total N ¼ 3154) met inclusion criteria. The pooled rates of the outcomes of interest were 4.7% (95% confidence interval, 3.5-6.2) for spinal cord ischemia, 7.6% (95% confidence interval, 5.0-11.5) for stroke, and 8.8% (95% confidence interval, 7.0-10.9) for operative mortality. The spinal cord ischemia event rate was higher with stent length 15 cm or greater or coverage to T8 or beyond than with stent length of 10 cm (11.6% vs 2.5%, P<.001). Adverse event rates in patients with acute type A aortic dissection versus nonacute dissection or aneurysm were as follows: mortality 9.2% versus 7.6% (P ¼ .46), stroke 9.3% versus 6.6% (P ¼ .51), and overall adverse events 22.0% versus 16.5% (P ¼ .41). Conclusions:As the frozen elephant trunk procedure becomes more popular, accurate data regarding outcomes are vital. We associated the frozen elephant trunk technique with (nonsignificantly) more adverse events overall in acute type A dissection cases. Stent length of 10 cm was associated with significantly less risk of spinal cord ischemia. Using a stent 15 cm or greater or coverage extending to T8 or farther should be avoided. (J Thorac Cardiovasc Surg 2020;160:20-33) 35 Studies 3154 Patients 4.7% SCI 7.6% Stroke 8.8% Mortality Extent of SC Coverage Dissection (Type A or DeBakey Type I) / Aneurysm, Nondissection Overall Adverse Event (Mortality / Stroke / SCI) ≥ 15 cm stent length / Coverage at or distal to T8 (6 studies / 201 patients)From the

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Section: Acute Type a Versus Nonacute Type A And Aneurysmmentioning

confidence: 99%

Neurologic complications after the frozen elephant trunk procedure: A meta-analysis of more than 3000 patients

Preventza

Liao

Olive

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

165

135

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“…This prevents kinking of the elephant trunk graft. The frozen elephant trunks for acute dissection are also an option (12,13).…”

Section: Elephant Trunk Proceduresmentioning

confidence: 99%

Protecting the brain and spinal cord in aortic arch surgery

Svensson¹

2018

Ann. Cardiothorac. Surg.

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Protection of the central nervous system-either the brain or the spinal cord-during aortic surgery has been the subject of intense research over the past several decades. While it took some 30 years to prove that some of the techniques first practiced in animals are valuable, surgeons can now take courage from 50 years of research that has resulted in superb outcomes, particularly when compared with historical results. Complex total arch operations and descending aortic operations can now be performed with less than a 2% rate of stroke, spinal cord injury, or death. Thoracoabdominal aortic operations and endovascular procedures have also become considerably safer with excellent results reported. The following review will discuss some of the historical outcomes, innovations, iterations, current techniques, and outcomes.

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“…4 Others have proposed a fenestrated FET, in which a hole is manually created in the stent portion of the graft and a covered stent is then released inside the LSA to seal the artery at the time of surgery. 5 In this issue of the Journal, Okamura and colleagues 6 have proposed a modification to further simplify the FET technique further in cases of acute type A aortic dissection. In a 3-step procedure, the Japanese team have deployed the hybrid prosthesis in the descending thoracic aorta, manually created a 10-mm hole into the graft to accommodate the ostium of the LSA, and, finally, reconstructed the remaining arch with separate reimplantation of the arch vessels.…”

Section: Davide Pacini MD Phd Giacomo Murana Md and Luca Di Marcmentioning

confidence: 99%