Evolution of Repetitive Sequences

Okada, Norihiro; Aono, Mitsuko; Endoh, Hiroshi; Kido, Yukiharu; Koishi, Ryuta; Matsumoto, K.; Matsuo, Mami; Murata, Shigenori; Nagahashi, Shigehisa; Yamaki, Toshifumi

doi:10.1007/978-4-431-68302-5_12

Cited by 2 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Rogers 1985;Weiner et al 1986). Recently, it was shown that SINEs are widespread in the animal kingdom (see, for recent reviews, Okada et al 1991;Okada 1991a,b) and also in plants (Mochizuki et al 1992;Yoshioka et al unpublished results). These recent findings indicate that retroposition by way of SINE amplification continuously generates genetic and structural variations in the genomes of many more animal and plant species than had previously been supposed.…”

mentioning

confidence: 95%

A model for the mechanism of initial generation of short interspersed elements (SINEs)

Okada

Ohshima

1993

J Mol Evol

Self Cite

View full text Add to dashboard Cite

Most animal genomes contain a large number of short interspersed elements (SINEs) that have a composite structure and contain a region that is homologous to a tRNA. The majority of SINEs have been found to be derived from a tRNA(Lys), being categorized as members of a superfamily of tRNA(Lys)-related SINEs. The consensus sequences of five SINEs that belong to this superfamily were aligned. It was found that, in the tRNA-unrelated region, there are two sequence motifs that are almost identical among these five SINEs and are at a distance of 10-11 nucleotides from each other. This observation suggests a common evolutionary origin of these SINEs and/or some function(s) for these motifs. Similar sequences were unexpectedly found to be present in the sequences complementary to the U5 regions of several mammalian retroviruses whose primer is a tRNA(Lys). On the basis of these findings, we propose a possible model for the generation of SINEs whereby they are derived from a "strong stop DNA" with a primer tRNA that is an intermediate in the process of reverse transcription of certain retroviruses.

show abstract

mentioning

confidence: 95%