Evolution of radiotherapeutic techniques

Brady, Luther W.; Lewis, George Cornewall; Antoniades, John; Prasasvinichai, Sriprayoon; Torpie, Richard J.; Asbell, Sucha O.; Glassburn, John R.; Schatanoff, David; MacMurray, Thomas

doi:10.1016/0090-8258(74)90022-5

Cited by 28 publications

(1 citation statement)

References 14 publications

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“…An additional argument in favour of intracavity therapy is that the incidence of vaginal vault metastases is considerably reduced when compared to other forms of radiotherapy (Brady et al, 1974;Lewis et al, 1977). In this series, 73% of uteri removed at surgery were shown to be "sterilized", but the dose delivered to the pelvic nodes would be minimal.…”

Section: Discussionmentioning

confidence: 87%

Prognostic Aspects of Endometrial Carcinoma

Svigos

Cox

Kirkland

et al. 1978

Aust NZ J Obst Gynaeco

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A retrospective analysis of 91 patients with endometrial carcinoma is presented with emphasis on important factors in relation to survival. Patients with Stage 1 carcinoma were treated with a standardized mode of preoperative radiation and extended abdominal hysterectomy. An 87.1% 5-year survival rate was obtained for patients with well differentiated lesions, with only 1 patient developing a vault metastasis. The assessment of residual tumour after intracavity radiotherapy proved reliable in predicting prognosis and should prove of benefit in directing additional therapy for endometrial carcinoma.

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Section: Discussionmentioning

confidence: 87%

Prognostic Aspects of Endometrial Carcinoma

Svigos

Cox

Kirkland

et al. 1978

Aust NZ J Obst Gynaeco

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Advances in the management of gynecologic cancer—radiation therapy

Brady

1975

Cancer

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Much progress has been made in the utilization of radiation therapy techniques in the management of gynecologic malignancies. However, new techniques will continue to emerge for the management of these disease processes. At this time, high LET radiation is particularly exciting, as are the potential possibilities for combined modality therapy. It is the expressed hope that these techniques will lead to imporved results in terms of management. The appropriate management for carcinoma of the uterus is excellent for the early stages, but treatments for later stages of the disease are not settled at this time. The high probability of involvement of periaortic lymph nodes in carcinoma of the cervix warrants a more appropriate look at the treatment techniques to be employed in the management of this disease, if the maximum potential for cure is expected. In carcinoma of the ovary, various factors influencing the ultimate prognosis have now been identified; these must be taken into consideration when planning treatment. If carcinoma is known or thought to have been left in the pelvis only, vigorous postoperative pelvic irradiation is mandatory. There isvidence to suggest, however, that equally good results can be obtained in those series by the utilization of chemotherapy. In view of the frequency of seeding to the peritoneum, whole abdominal irradiation should be considered for Stage IB through Stage III carcinoma of the ovary.

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Future prospects of radiotherapy in gynecologic oncology

Brady

1976

Cancer

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Major areas of progress in radiotherapy over the past decade have included important refinements in equipment and treatment techniques, as well as improved and expanded training programs for radiation oncologists. In 1975, approximately 14% of all new cancers were gynecologic, representing almost 68,000 new cases. Although end results in treatment of early cervix and corpus uteri lesions are quite good, results in treatment of early cervix and corpus uteri lesions are quite good, results in treatment of the later stage lesions, as well as ovarian and vulvo-vaginal tumors, are discouraging. Progress in the future will center around five primary areas: 1) greater understanding and utilization of radiation sensitizing agents such as hyperbaric oxygen, metronidazol, and other electroaffinic agents, purine and pyrimadine analogs, and antibiotics such as Actinomycin D and Adriamycin; 2) introduction into clinical use of high LET particle beams, such as fast neutrons, pi mesons, low atomic number nuclei, and heavy accelerated nuclei; 3) combined modality therapy utilizing radiation and chemotherapy or radiation and immunotherapy for management of subclinical disease; 4) radiobiologic and clinical advances in the utilization of radiation and hyperthermia; and 5) improved understanding of the pathophysiology and natural history of the gynecologic malignancies with increasing use of staging laparotomies, lymphangiography and peritoneoscopy.

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Evolution of radiotherapeutic techniques

Cited by 28 publications

References 14 publications

Prognostic Aspects of Endometrial Carcinoma

Prognostic Aspects of Endometrial Carcinoma

Advances in the management of gynecologic cancer—radiation therapy

Future prospects of radiotherapy in gynecologic oncology

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